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Ya. A. Zorkina
Publications - 27
Citations - 102
Ya. A. Zorkina is an academic researcher. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 11 publications receiving 57 citations.
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Journal ArticleDOI
Treatment of Poorly Differentiated Glioma Using a Combination of Monoclonal Antibodies to Extracellular Connexin-43 Fragment, Temozolomide, and Radiotherapy
G. M. Yusubalieva,Vladimir P. Baklaushev,Olga I. Gurina,Ya. A. Zorkina,I L Gubskii,G L Kobyakov,A. V. Golanov,S. A. Goryainov,Gorlachev Ge,A. N. Konovalov,Alexander Potapov,Vladimir P. Chekhonin +11 more
TL;DR: The results suggested that MAbE2Cx43 could be effective as the first-line drug in combined therapy for poorly differentiated gliomas in rats with induced C6 glioma.
Journal ArticleDOI
Neurobiological Highlights of Cognitive Impairment in Psychiatric Disorders
Anna Morozova,Ya. A. Zorkina,Olga Abramova,Olga Pavlova,Konstantin Pavlov,K.S. Soloveva,Maria V. Volkova,Polina A. Alekseeva,Alisa Andryshchenko,G. P. Kostyuk,Olga I. Gurina,Vladimir P. Chekhonin +11 more
TL;DR: This scientific review aims to summarize the current knowledge about neurobiological mechanisms of cognitive impairment in people with schizophrenia, depression, mild cognitive impairment and dementia (including Alzheimer’s disease).
Journal ArticleDOI
Effect of γ-irradiation on expression of tight and adherens junction protein mRNA on in vitro blood-brain barrier model.
Ya. A. Zorkina,N. E. Volgina,Gorlachev Ge,P. A. Mel’nikov,A. V. Golanov,Alexander Potapov,Vladimir P. Chekhonin +6 more
TL;DR: This model of blood–brain barrier in vitro can be used for studying the molecular mechanisms regulating permeability of cerebral endothelium under normal conditions and after pathological exposures, e.g. γ-irradiation.
Journal ArticleDOI
Post-Weaning Social Isolation Disturbs Gene Expression in Rat Brain Structures
E. A. Zubkov,Ya. A. Zorkina,E.V. Orshanskaya,N.N. Khlebnikova,N.A. Krupina,Vladimir P. Chekhonin +5 more
TL;DR: The data indicated the involvement of genes associated with the serotoninergic system in the mechanisms of mental disorders induced by post-weaning social isolation and suggest the gene encoding prolyl endopeptidase as a candidate gene involved in the pathogenesis of these disorders.
Journal ArticleDOI
[Blood-brain barrier permeability in healthy rats and rats with experimental C6 glioma after fractionated radiotherapy of the brain].
G. M. Yusubalieva,A. B. Levinskiy,Ya. A. Zorkina,Vladimir P. Baklaushev,S A Goryaynov,Galina Pavlova,P. A. Mel’nikov,Gorlachev Ge,A. V. Golanov,Alexander Potapov,Vladimir P. Chekhonin +10 more
TL;DR: Drug delivery to the brain can be improved using therapeutic doses of radiation treatment that affects the BBB and minimizes the risk of serious side effects that are often associated with the drug dose.