O
Olga Yuzhakov
Publications - 8
Citations - 1374
Olga Yuzhakov is an academic researcher. The author has contributed to research in topics: Antigen & Immunogenicity. The author has an hindex of 6, co-authored 6 publications receiving 737 citations.
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Journal ArticleDOI
Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses.
Kapil Bahl,Joe J Senn,Olga Yuzhakov,Alex Bulychev,Luis Brito,Kimberly J. Hassett,Michael E Laska,Michael D. Smith,Orn Almarsson,James G. Thompson,Amilcar Mick Ribeiro,Michael Watson,Tal Zaks,Giuseppe Ciaramella +13 more
TL;DR: These data show that LNP-formulated, modified mRNA vaccines can induce protective immunogenicity with acceptable tolerability profiles, demonstrating robust prophylactic immunity in humans.
Journal ArticleDOI
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Kimberly J. Hassett,Kerry Benenato,Eric Jacquinet,Aisha Lee,Angela Woods,Olga Yuzhakov,Sunny Himansu,Jessica Deterling,Benjamin M. Geilich,Tatiana Ketova,Cosmin Mihai,Andy Lynn,Iain Mcfadyen,Melissa J. Moore,Joseph J. Senn,Matthew G. Stanton,Orn Almarsson,Giuseppe Ciaramella,Luis Brito +18 more
TL;DR: Screening a panel of proprietary biodegradable ionizable lipids for both expression and immunogenicity in a rodent model shows that mRNA vaccine tolerability can be improved without affecting potency.
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Efficient Targeting and Activation of Antigen-Presenting Cells In Vivo after Modified mRNA Vaccine Administration in Rhesus Macaques
Frank Liang,Gustaf Lindgren,Ang Lin,Elizabeth A. Thompson,Sebastian Ols,Josefine Röhss,Shinu John,Kimberly J. Hassett,Olga Yuzhakov,Kapil Bahl,Luis Brito,Hugh Salter,Giuseppe Ciaramella,Karin Loré +13 more
TL;DR: It is shown that modified non-replicating mRNA encoding influenza H10 hemagglutinin and encapsulated in lipid nanoparticles (LNP) induce protective HA inhibition titers and H10-specific CD4+ T cell responses after intramuscular or intradermal delivery in rhesus macaques.
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Multi-antigenic human cytomegalovirus mRNA vaccines that elicit potent humoral and cell-mediated immunity.
Shinu John,Olga Yuzhakov,Angela Woods,Jessica Deterling,Kimberly J. Hassett,Christine A. Shaw,Giuseppe Ciaramella +6 more
TL;DR: It is demonstrated that the immunization of mice and nonhuman primates with lipid nanoparticles encapsulating modified mRNA encoding CMV glycoproteins gB and pentameric complex (PC) elicit potent and durable neutralizing antibody titers.
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Induction of Robust B Cell Responses after Influenza mRNA Vaccination Is Accompanied by Circulating Hemagglutinin-Specific ICOS+ PD-1+ CXCR3+ T Follicular Helper Cells.
Gustaf Lindgren,Sebastian Ols,Frank Liang,Elizabeth A. Thompson,Ang Lin,Fredrika Hellgren,Kapil Bahl,Shinu John,Olga Yuzhakov,Kimberly J. Hassett,Luis Brito,Hugh Salter,Giuseppe Ciaramella,Karin Loré +13 more
TL;DR: It is demonstrated that modified non-replicating mRNA encoding influenza H10 encapsulated in lipid nanoparticles (LNP) in non-human primates potently induce an immunological repertoire associated with the generation of high magnitude and quality antibodies.