T
Tatiana Ketova
Researcher at Vanderbilt University Medical Center
Publications - 19
Citations - 1947
Tatiana Ketova is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Cancer & Sonic hedgehog. The author has an hindex of 15, co-authored 18 publications receiving 1230 citations. Previous affiliations of Tatiana Ketova include Vanderbilt University & National Institutes of Health.
Papers
More filters
Journal ArticleDOI
Directional cell movement through tissues is controlled by exosome secretion
TL;DR: In this paper, the authors used intravital imaging to demonstrate that secretion of exosomes from late endosomes is required for directionally persistent and efficient in vivo movement of cancer cells.
Journal ArticleDOI
Optimization of Lipid Nanoparticles for Intramuscular Administration of mRNA Vaccines
Kimberly J. Hassett,Kerry Benenato,Eric Jacquinet,Aisha Lee,Angela Woods,Olga Yuzhakov,Sunny Himansu,Jessica Deterling,Benjamin M. Geilich,Tatiana Ketova,Cosmin Mihai,Andy Lynn,Iain Mcfadyen,Melissa J. Moore,Joseph J. Senn,Matthew G. Stanton,Orn Almarsson,Giuseppe Ciaramella,Luis Brito +18 more
TL;DR: Screening a panel of proprietary biodegradable ionizable lipids for both expression and immunogenicity in a rodent model shows that mRNA vaccine tolerability can be improved without affecting potency.
Journal ArticleDOI
A Novel Amino Lipid Series for mRNA Delivery: Improved Endosomal Escape and Sustained Pharmacology and Safety in Non-human Primates
Staci Sabnis,E. Sathyajith Kumarasinghe,Timothy Salerno,Cosmin Mihai,Tatiana Ketova,Joseph J. Senn,Andy Lynn,Alex Bulychev,Iain Mcfadyen,Joyce Chan,Orn Almarsson,Matthew G. Stanton,Kerry Benenato +12 more
TL;DR: Clear structure-activity relationships were developed that resulted in a new amino lipid that affords efficient mRNA delivery in rodent and primate models with optimal pharmacokinetics and is the first example of the ability to safely repeat dose mRNA-containing lipid nanoparticles in non-human primate at therapeutically relevant levels.
Journal ArticleDOI
Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA.
Siddharth Patel,N. Ashwanikumar,Ema Robinson,Yan Xia,Cosmin Mihai,Joseph P. Griffith,Shangguo Hou,Adam A. Esposito,Tatiana Ketova,Kevin Welsher,John L. Joyal,Orn Almarsson,Gaurav Sahay,Gaurav Sahay +13 more
TL;DR: Structure-activity analysis of cholesterol analogues reveals that incorporation of C-24 alkyl phytosterols into LNPs (eLNPs) enhances gene transfection and the length ofAlkyl tail, flexibility of sterol ring and polarity due to -OH group is required to maintain high transfections.
Journal ArticleDOI
Transventricular delivery of Sonic hedgehog is essential to cerebellar ventricular zone development.
Xi Huang,Jiang Liu,Tatiana Ketova,Jonathan T. Fleming,Vandana K. Grover,Michael K. Cooper,Ying Litingtung,Chin Chiang +7 more
TL;DR: It is demonstrated that the cerebellum is not the source of Shh that signals to the early VZ, and a transventricular path for Shh ligand delivery is suggested, underscoring the potential contribution of VZ progenitors in the pathogenesis of cerebellar diseases associated with deregulated Shh signaling.