O
Oliver Fuerst
Researcher at Autonomous University of Barcelona
Publications - 2
Citations - 31
Oliver Fuerst is an academic researcher from Autonomous University of Barcelona. The author has contributed to research in topics: Melibiose & Binding site. The author has an hindex of 2, co-authored 2 publications receiving 28 citations.
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Journal ArticleDOI
The Melibiose Transporter of Escherichia coli: CRITICAL CONTRIBUTION OF LYS-377 TO THE STRUCTURAL ORGANIZATION OF THE INTERACTING SUBSTRATE BINDING SITES.
Oliver Fuerst,Yibin Lin,Meritxell Granell,Gérard Leblanc,Esteve Padrós,Víctor A. Lórenz-Fonfría,Víctor A. Lórenz-Fonfría,Josep Cladera +7 more
TL;DR: The analysis of the second-site revertants of K377C reveals that mutation of Ile-22 (in helix I) preserves Na+ binding, whereas that of melibiose is largely abolished according to spectroscopic measurements, highlighting the crucial role of the Lys-377 residue in the spatial organization of the Na+binding site.
Journal ArticleDOI
The substitution of Arg149 with Cys fixes the melibiose transporter in an inward-open conformation
Yibin Lin,Oliver Fuerst,Meritxell Granell,Gérard Leblanc,Víctor A. Lórenz-Fonfría,Esteve Padrós +5 more
TL;DR: It is concluded that Arg149, most likely located in the inner (cytoplasmic) half of transmembrane helix 5, is critically involved in the reorientation mechanism of the substrate-binding site accessibility in MelB.