Oliver Yoa Pu Hu

TL;DR: Drug release rates for the disks were found to be a function of drug solubility, with higher drug release ratesFor disks loaded with more hydrophilic prodrugs and an increased amount of beta-cyclodextrin, and the CP/HPC ratio had no impact on the release of nalbuphine hydrochloride.

TL;DR: The feasibility of using submicron lipid emulsion as the parenteral drug delivery system for nalbuphine and its prodrugs is demonstrated and the in vivo analgesic activity correlated well to the profiles of in vivo pharmacokinetic profiles.

TL;DR: This is the first report of a cell line, animal, and clinical trial confirming that the metabolite 5-OH-PA is responsible for PZA-induced hepatotoxicity.

TL;DR: The nalbuphine propionate release profiles fit well to the Higuchi expression, indicating that drug release from the Poly ( d,l -lactide-co-glycolide) based matrices was consistent with a diffusion mechanism, suggesting that different polymer compositions may attribute to various matrix hydration and therefore affect drug releaseFrom the PLGA matrices.

TL;DR: The use of a sensitivity index as a possible criterion for regulatory authorities in the new region to evaluate whether a bridging clinical study should be conducted and the sample size of such a bridges clinical study is proposed.