Olivia Felt

TL;DR: This review presents a critical analysis of covalently and ionically crosslinked chitosan hydrogels and related networks for medical or pharmaceutical applications and discusses with reference to the specific chemical interactions, which dictate gel formation.

TL;DR: The aim of this review was to provide a detailed overview of physical chitosan hydrogels and related networks formed by aggregation or complexation, which are intended for biomedical applications, with particular emphasis on the network-forming interactions, the principles governing their formation and their physicochemical properties.

TL;DR: The aim of this review is to give an insight into the many potential applications of chitosan as a pharmaceutical drug carrier.

TL;DR: The mucoadhesive polysaccharide chitosan was evaluated as a potential component in ophthalmic gels for enabling increased precorneal drug residence times and showed excellent tolerance after topical administration onto the corneal surface.

TL;DR: In vitro evaluation showed that concentrations of chitosan as low as 0.0375% still exert a bacteriostatic effect against E. coli and S. aureus, and Gamma scintigraphic studies demonstrated that chitOSan formulations remain on the precorneal surface as long as commonly used commercial artificial tears having a 5-fold higher viscosity.