O
Olivier Gardon
Researcher at University of Queensland
Publications - 2
Citations - 334
Olivier Gardon is an academic researcher from University of Queensland. The author has contributed to research in topics: Glycoprotein 130 & Cytokine receptor. The author has an hindex of 2, co-authored 2 publications receiving 275 citations.
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Journal ArticleDOI
Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor
Andrew J. Brooks,Wei Dai,Megan L. O'Mara,Daniel Abankwa,Yash Chhabra,Rebecca A. Pelekanos,Olivier Gardon,Kathryn A. Tunny,Kristopher M. Blucher,Craig J. Morton,Michael W. Parker,Michael W. Parker,Emma Sierecki,Yann Gambin,Guillermo A. Gomez,Kirill Alexandrov,Ian A. Wilson,Manolis Doxastakis,Alan E. Mark,Michael J. Waters +19 more
TL;DR: The mechanism provides a molecular basis for understanding the oncogenic JAK2 mutations responsible for polycythemia vera and certain other hematologic disorders and may thus be of value in the design of small-molecule inhibitors of clinical applicability.
Journal ArticleDOI
S-7 : A new cytokine receptor activation paradigm: Activation of JAK2 by the growth hormone receptor
Andrew J. Brooks,Yash Chhabra,Daniel Abankwa,Megan L. O'Mara,Wei Dai,Olivier Gardon,Kathryn A. Tunny,Kristopher M. Blucher,Craig J. Morton,Michael W. Parker,Emma Sierecki,Yann Gambin,Guillermo A. Gomez,Kirill Kirill Alexandrov,Manolis Doxastakis,Alan E. Mark,Michael J. Waters +16 more
TL;DR: In this article, the authors used FRET to monitor positioning of the JAK2 binding motif, Jun-zipper receptor constructs to control receptor transmembrane (TM) helix position, atomistic modeling of TM helix interactions and docking of JAK 2 kinase and inhibitory pseudokinase crystal structures with an opposing pair in trans.