Showing papers in "Cytokine in 2014"

TL;DR: This review summarizes current knowledge of regulatory mechanisms that control and regulate the dynamic expression of IL-6 and its two receptors and suggests a much more complex situation.

TL;DR: The presence of inflammatory cytokines in the osteoarthritic joint raises the question whether they may directly participate in pain generation by acting on innervating joint nociceptors, and what is known about their contribution to joint pain based on studies in animal models.

TL;DR: This study examined serum proinflammatory markers interleukin(IL)-6, IL-8, tumor necrosis factor (TNF-α), IL-1β, and C-reactive protein during each trimester of pregnancy and 4-6 weeks postpartum among 57 women to determine the extent to which obesity-induced inflammation affects maternal and fetal health.

TL;DR: This review examines how various inflammasomes promote the release of IL-1β, IL-18 and HMGB1 to combat pathogenic situations and plays distinct roles during sterile inflammation, responding to viral, bacterial and parasite infection, and tailoring the innate immune response to specific threats.

TL;DR: IL-10 and TGF-β are cytokines that appear to be more involved in modulation of immune response in CL and ML patients, and might have a protective role, since the neutralization of IFN-γ decreases the production of TNF-α in an IL-10-dependent manner.

TL;DR: The concentration of interleukin (IL)-18 was strikingly elevated in the patients presented with HLH, and remained high after the recovery from HLH although levels of other pro-inflammatory cytokines approached the normal range.

TL;DR: This manuscript provides an overview of different approaches employed by the pharmaceutical industry and CROs, for the use and application of CRA based upon a survey and post survey follow up conducted by ILSI-Health and Environmental Sciences Institute (HESI) Immunotoxicology Committee CRA Working Group.

TL;DR: APS significantly improved experimental TNBS-induced colitis in rats through regulation of TNF-α, IL-1β and NFATc4 expression and improved both macroscopic and microscopic scores.

TL;DR: The myokine irisin is independently associated with FI in pregnancy and fasting insulin (FI) was independently and positively associated with serum irisin in multivariate analysis during pregnancy.

TL;DR: IL-35 is produced by PCAN in vivo and promotes PCAN cell line growth in vitro and may indicate an important new role for IL-35 as an autocrine growth factor in PCAN growth.

TL;DR: Results indicate that P. gingivalis is a major contributor to the altered immune responses and the pathology of periodontitis, and the ease of sampling and analyzing cytokine expression profiles, including TGF-β1, in saliva and GCF may serve to predict the progression ofperiodontitis and associated systemic inflammatory diseases.

TL;DR: Depletion of NK and Th17 cells along with a not compromised Treg compartment delineate the existence of an "immune profile" that argue against the recent hypothesis of IPF as an autoimmune disease.

TL;DR: Elevated sTREM-1 could be considered an early marker for NS that reflects sepsis severity and poor prognosis and was significantly higher in neonates with early sepsi than late sepsIS and was associated with high mortality.

TL;DR: All but viral and bacterial meningitis, studied, displayed higher means of elevated lymphokine concentrations in the serum than in the CSF, which supports the concept of immunological crosstalk between periphery and intrathecal immunity in neurological and psychiatric diseases.

TL;DR: It is demonstrated that IL-32 plays a role in the tumor-associated inflammatory microenvironment and that overexpression of IL- 32 contributes to invasion and metastasis in primary lung adenocarcinoma, suggesting that it may have clinical utility as a prognostic biomarker and potential target for immunotherapy in lung adentheses.

TL;DR: Results showed an additive effect on angiogenesis of mCRP stimulatory effect combined with Notch-3/Fc promoting bovine aortic endothelial cell (BAEC) proliferation, migration, tube formation in Matrigel(TM) with up-regulation of phospho-Akt expression.

TL;DR: It is concluded that human monocytes from healthy individuals and kidney transplant recipients possess the capacity to produce IFN-γ.

TL;DR: The signal for serum IL-18 located on chromosome two is novel and potentially important in inflammasome triggered chronic activation of inflammation in older adults as well as molecular studies to better understand the role of NLRC4.

TL;DR: The relationship between innate immunity and SS pathogenesis prior to overt disease onset is explored and therapeutic strategies to mitigate disease progression in SS patients are discussed.

TL;DR: A pro-inflammatory response of dermal fibroblasts to LMWHA that was transferred to leukocytes indicating the significance of LMW HA in the inflammatory process development during the wound healing process.

TL;DR: It is demonstrated that SCA patients have increased inflammatory profile when compared to the healthy individuals and genetic polymorphisms in sickle cell anemia are associated with the inflammatory profile.

TL;DR: In this paper, the authors evaluated tumour necrosis factor-alpha (TNF-α), interleukin (IL)-6, interferon gamma (IFN-γ) and transforming growth factor-beta1 (TGF-β1) in hepatitis E infection during pregnancy and its relation with pregnancy outcome.

TL;DR: It is suggested that IL-17F 7488G allele is associated with increased lung cancer risk in the Tunisian population, and the existence of a biological interaction between IL- 17A, but not IL-16F polymorphisms and smoking is suggested.

TL;DR: It is suggested that lincRNAs are novel intracellular molecular effectors of specific cytokines in cells of the innate immune system in humans in vivo and that they might be involved in the molecular pathophysiology of rheumatoid arthritis.

TL;DR: The role of chemokine ligands in the migration of immune cells, multipotent stem cells, and progenitor cells has been investigated in the setting of tissue regeneration as discussed by the authors.

TL;DR: It is shown that the expressions of co-inhibitors on NK cells, including LAG-3, PD-1, and TIGIT, are differently regulated by cytokines IL-10,IL-12, IL-15, IFN-α, andTGF-β, providing an initial information on the expression regulation ofCo-Inhibitors in human NK cells.

TL;DR: The cytokine levels in aqueous humor of Colombian patients with active ocular toxoplasmosis were determined and specific cytokine-patterns with clinical characteristics and with the infecting Toxoplasma strain were correlated for the first time.

TL;DR: TGF-β1 protected against apoptosis of AF cells under starvation through down-regulating excessive autophagy through PI3K-AKT-mTOR and MAPK-ERK1/2 were the possible signaling pathways involved in this process.

TL;DR: This review deals with the role of IL-6 on hepatic lipid metabolism and analyzes various data presented on this topic.

TL;DR: It is demonstrated that neutrophils have a dynamic role during host immune response to P. brasiliensis, since they have the capacity to modulate innate and adaptative immune response against this fungus by producing cytokines and lipidic mediators.