Megan L. O'Mara

TL;DR: The mechanism provides a molecular basis for understanding the oncogenic JAK2 mutations responsible for polycythemia vera and certain other hematologic disorders and may thus be of value in the design of small-molecule inhibitors of clinical applicability.

TL;DR: Seven complete prokaryotic structures and one eukaryotic structure have been solved for transporters from 2002 to date, and a wealth of research is being conducted on and around these structures to resolve the mechanistic conundrum of how this mechanism couple ATP hydrolysis in cytosolic domains to substrate translocation through the transmembrane pore.

TL;DR: The data show that the RyR2 gate directly senses luminal (store) Ca2+, explaining the regulation ofRyR2 by luminal Ca2+ by the initiation of Ca1+ waves and Ca2-triggered arrhythmias.

TL;DR: A potential mechanism for the TAP protein is outlined with supporting evidence from bacterial transporter structures and the notion that ABC transporters in general have adapted around a universal transport mechanism is supported.

TL;DR: The function of the known ABC transporters in E. coli is summarized and mechanistic insights from structural and computational studies are summarized and computational approaches involving modeling and simulation are beginning to yield insight into the dynamics of thetransporters.