O
Olivier Staub
Researcher at University of Lausanne
Publications - 102
Citations - 9240
Olivier Staub is an academic researcher from University of Lausanne. The author has contributed to research in topics: Epithelial sodium channel & Ubiquitin ligase. The author has an hindex of 47, co-authored 95 publications receiving 8584 citations. Previous affiliations of Olivier Staub include University of Zurich & University of Toronto.
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Journal ArticleDOI
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.
TL;DR: The results demonstrate that the WW domains of rNedd4 bind to the PY motifs deleted from beta or gammaENaC in Liddle's syndrome patients, and suggest that Nedd4 may be a regulator (suppressor) of the epithelial Na+ channel.
Journal ArticleDOI
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination.
Olivier Staub,Ivan Gautschi,Toru Ishikawa,Kristin Breitschopf,Aaron Ciechanover,Laurent Schild,Daniela Rotin +6 more
TL;DR: It is shown that ENaC is a short‐lived protein that is ubiquitinated in vivo on the α and γ (but not β) subunits, and a paradigm for ubiquitination‐mediated regulation of ion channels is proposed.
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Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression
Christophe Debonneville,Christophe Debonneville,Sandra Y. Flores,Sandra Y. Flores,Elena Kamynina,Pamela J. Plant,Caroline Tauxe,Marc A. Thomas,Carole Münster,Ahmed Chraibi,J. Howard Pratt,Jean-Daniel Horisberger,David A. Pearce,Johannes Loffing,Olivier Staub +14 more
TL;DR: It is shown that phosphorylation of an enzyme involved in the ubiquitylation cascade (Nedd4‐2) controls cell surface density of ENaC and a paradigm for the control of ion channels is proposed.
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Ubiquitination and endocytosis of plasma membrane proteins: role of Nedd4/Rsp5p family of ubiquitin-protein ligases.
TL;DR: Accumulating evidence suggests that, at least in yeast, ubiquitin itself may constitute an internalization signal, recognized by a hypothetical receptor, as well as a role in the endocytic process possibly involving its C2 domain, in addition to its role in ubiquitinating endocytosed proteins.
Journal ArticleDOI
Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome
Hugues Abriel,Johannes Loffing,John F. Rebhun,J. Howard Pratt,Laurent Schild,Jean-Daniel Horisberger,Daniela Rotin,Olivier Staub +7 more
TL;DR: It is demonstrated that Nedd4 is a negative regulator of ENaC and suggested that the loss of Nedd 4 binding sites in EN aC observed in Liddle's syndrome may explain the increase in channel number at the cell surface, increased Na+ reabsorption by the distal nephron, and hence the hypertension.