M
Marc A. Thomas
Researcher at University of Lausanne
Publications - 10
Citations - 1263
Marc A. Thomas is an academic researcher from University of Lausanne. The author has contributed to research in topics: Transcription factor & Gene expression. The author has an hindex of 9, co-authored 10 publications receiving 1194 citations. Previous affiliations of Marc A. Thomas include Geneva College.
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Journal ArticleDOI
Phosphorylation of Nedd4‐2 by Sgk1 regulates epithelial Na+ channel cell surface expression
Christophe Debonneville,Christophe Debonneville,Sandra Y. Flores,Sandra Y. Flores,Elena Kamynina,Pamela J. Plant,Caroline Tauxe,Marc A. Thomas,Carole Münster,Ahmed Chraibi,J. Howard Pratt,Jean-Daniel Horisberger,David A. Pearce,Johannes Loffing,Olivier Staub +14 more
TL;DR: It is shown that phosphorylation of an enzyme involved in the ubiquitylation cascade (Nedd4‐2) controls cell surface density of ENaC and a paradigm for the control of ion channels is proposed.
Journal ArticleDOI
Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination.
Miguel X. van Bemmelen,Jean-Sébastien Rougier,Bruno Gavillet,Florine Apothéloz,Dorothée Daidié,Michihiro Tateyama,Ilaria Rivolta,Marc A. Thomas,Robert S. Kass,Olivier Staub,Hugues Abriel +10 more
TL;DR: It is demonstrated that Nav 1.5 can be ubiquitinated in heart tissues and that the ubiquitin-protein ligase Nedd4-2 acts on Nav1.5 by decreasing the channel density at the cell surface.
Journal ArticleDOI
A tyrosine-based sorting signal is involved in connexin43 stability and gap junction turnover
TL;DR: Results provide strong evidence that the tyrosine-based motif of human connexin43 is a prime determinant controlling con Nexin43 stability, and consequently GJC, by targeting connex in43 for degradation in the endocytic/lysosomal compartment.
Journal ArticleDOI
Cardiac sodium channel Na(v)1.5 interacts with and is regulated by the protein tyrosine phosphatase PTPH1.
Thomas Jespersen,Bruno Gavillet,Miguel X. van Bemmelen,Sophie Cordonier,Marc A. Thomas,Olivier Staub,Hugues Abriel,Hugues Abriel +7 more
TL;DR: The results of this study suggest that tyrosine phosphorylation destabilizes the inactivated state of Na(v)1.5.
Journal ArticleDOI
Role of nuclear factor of activated T cells (NFAT) in the expression of interleukin-5 and other cytokines involved in the regulation of hemopoetic cells.
TL;DR: Experimental data is provided to show that the binding of NFAT to the nucleotides GAA at positions -113 to -111 of the human IL5 promoter is associated with functional activity in human T cells.