O
Olivier Wurtz
Researcher at French Institute of Health and Medical Research
Publications - 19
Citations - 1928
Olivier Wurtz is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Receptor & IL-2 receptor. The author has an hindex of 10, co-authored 17 publications receiving 1751 citations. Previous affiliations of Olivier Wurtz include Centre national de la recherche scientifique & University of Rouen.
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Journal ArticleDOI
Pituitary Adenylate Cyclase-Activating Polypeptide and Its Receptors: 20 Years after the Discovery
David Vaudry,Anthony Falluel-Morel,Steve Bourgault,Magali Basille,Delphine Burel,Olivier Wurtz,Alain Fournier,Billy K. C. Chow,Hitoshi Hashimoto,Ludovic Galas,Hubert Vaudry +10 more
TL;DR: The present report reviews the current knowledge concerning the pleiotropic actions of PACAP and discusses its possible use for future therapeutic applications.
Journal ArticleDOI
Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork
Pierre-François Lenne,Pierre-François Lenne,L. Wawrezinieck,Fabien Conchonaud,Fabien Conchonaud,Olivier Wurtz,Olivier Wurtz,Annie Boned,Annie Boned,Xiao-Jun Guo,Hervé Rigneault,Hervé Rigneault,Hai-Tao He,Hai-Tao He,Didier Marguet,Didier Marguet +15 more
TL;DR: A free‐like diffusion was observed when both the lipid‐dependent and cytoskeleton‐based organizations were disrupted, which suggests that these are two main compartmentalizing forces at work in the plasma membrane.
Journal ArticleDOI
Repeated Antigen Exposure Is Necessary for the Differentiation, But Not the Initial Proliferation, of Naive CD4+ T Cells
TL;DR: It is shown that initial Ag stimulation induces in CD4+ T cells a program of proliferation that can develop, for at least seven cycles of division, in the absence of subsequent Ag or cytokine requirement.
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IL‐4‐mediated inhibition of IFN‐γ production by CD4+ T cells proceeds by several developmentally regulated mechanisms
TL;DR: It is shown here that IL-4 affects Th1 cell responses by two developmentally regulated mechanisms, which may explain why Th1 and Th2 responses can co-exist in vivo although Th2 effector cells dominate functionally, as observed in some infectious or autoimmune mice models.
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Delayed Pituitary Adenylate Cyclase–Activating Polypeptide Delivery After Brain Stroke Improves Functional Recovery by Inducing M2 Microglia/Macrophage Polarization
TL;DR: The results demonstrated that immunomodulatory strategies capable of redirecting the microglial response toward a neuroprotective M2 phenotype in the late phase of brain ischemia could represent attractive options for stroke treatment in a new and unexploited therapeutical window.