Olli-Pekka Pitkänen

TL;DR: Coronary flow reserve is impaired in young adult males with IDDM and no or minimal microvascular complications and without any evidence of coronary heart disease, which implies early impairment of coronary vascular reactivity in IDDM patients, which may represent an early precursor of future coronary heart diseases or contribute to the pathogenesis of diabetic cardiomyopathy.

TL;DR: Evidence is provided for the role of ox-LDL in affecting the coronary reactivity in vivo and support the concept that oxidative modification of LDL particles provides a mechanism by which high LDL concentrations exhibit injurious effects on the coronary vascular bed.

TL;DR: Abnormalities in coronary flow regulation exist in young asymptomatic FCHL patients expressing phenotype IIB (characterized by abnormalities in both serum cholesterol and triglyceride concentrations), which is in line with previous observations suggesting that the metabolic abnormalities related to the pathophysiology of F CHL are associated with the phenotype IIA.

TL;DR: Changes in vascular physiology associated with early atherosclerosis, as assessed by positron emission tomography imaging with intravenous dipyridamole, would be related to risk factor variables in healthy young men, correlated significantly with coronary flow reserve.

TL;DR: The possible modulating effect of previous nickel sensitization on subsequent cobalt sensitization, and vice versa, was studied in a guinea pig model, using an open epicutanous induction protocol.