Thank you for downloading design of analog cmos integrated circuits. Maybe you have knowledge that, people have look hundreds times for their chosen books like this design of analog cmos integrated circuits, but end up in malicious downloads. Rather than enjoying a good book with a cup of coffee in the afternoon, instead they juggled with some harmful virus inside their computer. design of analog cmos integrated circuits is available in our book collection an online access to it is set as public so you can download it instantly. Our digital library spans in multiple countries, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the design of analog cmos integrated circuits is universally compatible with any devices to read.

Design Of Analog Cmos Integrated Circuits

Digital health facilitated by wearable/portable electronics and big data analytics holds great potential in empowering patients with real‐time diagnostics tools and information. The detection of a majority of biomarkers at trace levels in body fluids using mobile health (mHealth) devices requires bioaffinity sensors that rely on “bioreceptors” for specific recognition. Portable point‐of‐care testing (POCT) bioaffinity sensors have demonstrated their broad utility for diverse applications ranging from health monitoring to disease diagnosis and management. In addition, flexible and stretchable electronics‐enabled wearable platforms have emerged in the past decade as an interesting approach in the ambulatory collection of real‐time data. Herein, the technological advancements of mHealth bioaffinity sensors evolved from laboratory assays to portable POCT devices, and to wearable electronics, are synthesized. The involved recognition events in the mHealth affinity biosensors enabled by bioreceptors (e.g., antibodies, DNAs, aptamers, and molecularly imprinted polymers) are discussed along with their transduction mechanisms (e.g., electrochemical and optical) and system‐level integration technologies. Finally, an outlook of the field is provided and key technological bottlenecks to overcome identified, in order to achieve a new sensing paradigm in wearable bioaffinity platforms.

/pdf/the-era-of-digital-health-a-review-of-portable-and-wearable-tj8im9v8mn.pdf

The Era of Digital Health: A Review of Portable and Wearable Affinity Biosensors

This paper presents a low-power and high-precision voltage and current reference (VCR) in one simple circuit. The voltage reference is derived from the threshold voltage difference between an I/O (i.e., 3.3-V NMOS) and standard (i.e., 1.8-V NMOS) transistors with temperature-independent bias current, and the current reference is the voltage reference divided by a temperature-insensitive resistor. The resistor is made up by series connection of a proportional-to-absolute-temperature (PTAT) NWELL resistor and a complementary-to-absolute-temperature (CTAT) high-resistance poly resistor in series. Implemented in a standard 0.18- $\mu \text{m}$ CMOS process, the proposed VCR circuit takes an active area of only 0.055 mm2. The measured voltage and current references ( $\text{V}_{\mathrm {ref}}$ and $\text{I}_{\mathrm {ref}}$ ) at room temperature are 368 mV and 9.77 nA, respectively. The measured average temperature coefficient (TC) of $\text{V}_{\mathrm {ref}}$ and $\text{I}_{\mathrm {ref}}$ are 43.1 ppm/°C and 149.8 ppm/°C over a temperature range of −40~125°C with one-time trimming and the variation coefficients are 0.35% and 1.6%, respectively. The measured voltage and current line sensitivities are 0.027%/V and 0.6%/V, respectively. The minimum supply voltage is 0.7 V with a total power consumption of 28 nW. The measured power supply ripple rejection (PSRR) of $\text{V}_{\mathrm {ref}}$ is −65 dB @DC and −39.4 dB at frequencies higher than 1 Hz.

A 0.7-V 28-nW CMOS Subthreshold Voltage and Current Reference in One Simple Circuit

Aptamers are synthetic bio-receptors of deoxyribonucleic acid (DNA) or ribonucleic acid (RNA) origin selected by the systematic evolution of ligands (SELEX) process that bind a broad range of target analytes with high affinity and specificity. So far, electrochemical biosensors have come up as a simple and sensitive method to utilize aptamers as a bio-recognition element. Numerous aptamer based sensors have been developed for clinical diagnostics, food, and environmental monitoring and several other applications are under development. Aptasensors are capable of extending the limits of current analytical techniques in clinical diagnostics, food, and environmental sample analysis. However, the potential applications of aptamer based electrochemical biosensors are unlimited; current applications are observed in the areas of food toxins, clinical biomarkers, and pesticide detection. This review attempts to enumerate the most representative examples of research progress in aptamer based electrochemical biosensing principles that have been developed in recent years. Additionally, this account will discuss various current developments on aptamer-based sensors toward heavy metal detection, for various cardiac biomarkers, antibiotics detection, and also on how the aptamers can be deployed to couple with antibody-based assays as a hybrid sensing platform. Aptamers can be used in various applications, however, this account will focus on the recent advancements made toward food, environmental, and clinical diagnostic application. This review paper compares various electrochemical aptamer based sensor detection strategies that have been applied so far and used as a state of the art. As illustrated in the literature, aptamers have been utilized extensively for environmental, cancer biomarker, biomedical application, and antibiotic detection and thus have been extensively discussed in this article.

https://www.mdpi.com/1424-8220/19/24/5435/pdf

Application of Electrochemical Aptasensors toward Clinical Diagnostics, Food, and Environmental Monitoring: Review

A review of biosensor technologies for blood biomarkers toward monitoring cardiovascular diseases at the point-of-care.

This paper presents a wide range, voltage controlled-current source circuit that is optimized to compensate for both process and temperature variations. Compensation for process variations is realized by cancellation of the threshold voltage variations. Temperature compensation is applied by the use of a poly resistor. Ninety samples from 3 different chips of the same wafer run were measured, and for the nominal value of 25 nA, current sources have a standard deviation of 1.22% (4.8 × improvement over an uncompensated current reference). The simulated standard deviation is 8%, resulting a simulated improvement factor of 8×, when samples from different wafer runs are to be measured. Measured temperature drift is 250 ppm/°C for a temperature range of 0-80°C. For the mentioned performance, the circuit consists of only 7 components occupying an area of 64 μm × 91 μm, using AMS 0.35 μm, 5 V CMOS process technology. The new current source is used to mimic the behavior of an infrared detector, which creates current in the range of 1-50 nA. A modified version of proposed current source is also designed with no off-chip bias voltages, and has a temperature coefficient of 57 ppm°C for 9 nA with an acceptable process compensation.

Wide Range, Process and Temperature Compensated Voltage Controlled Current Source

A new digital readout integrated circuit (DROIC) with pixel parallel A/D conversion and reduced quantization noise

This paper presents a new self-calibration method for vector-sum phase shifters (PS) to compensate for process variations and achieve reconfigurable operating frequency. The calibration system generates a look-up table for the control voltages of the variable-gain amplifiers of the PS to minimize the rms phase error at a frequency of interest. The calibration system consists of a coupled-line coupler, an amplifier, a power detector (PD), an analog-to-digital converter, and a data processing unit. In this calibration method, first, the amplitudes of IQ vectors are swept and their powers are measured. Then, phase errors are calculated from these power measurements using the cosine formula. Finally, the vector pairs providing the least phase error are chosen for each desired phase shift. The practicality of the proposed system is demonstrated by realizing a self-calibrated $X$ -band 7-b PS fabricated in IHP 0.25- $\mu \text{m}$ SiGe BiCMOS technology, including the on-chip coupler, amplifier, and PD. The calibration system improves the rms phase error by at least 1°, does not degrade the rms gain error, and increases the insertion loss by 1.6 dB. The self-calibrated PS achieves a 2° rms phase error across $X$ -band frequencies. The overall chip size is 2.6 mm2. The power consumption of the PS and the overall system are 110 and 233 mW, respectively. This built-in calibration system mitigates process variation effects, and the performance of the PS can be optimized for any center frequency across $X$ -band.

A Phase-Calibration Method for Vector-Sum Phase Shifters Using a Self-Generated LUT

Design of a silicon readout integrated circuit (ROIC) for LWIR HgCdTe Focal Plane is presented. ROIC incorporates
time delay integration (TDI) functionality over seven elements with a supersampling rate of three, increasing SNR and
the spatial resolution. Novelty of this topology is inside TDI stage; integration of charges in TDI stage implemented in
current domain by using switched current structures that reduces required area for chip and improves linearity
performance. ROIC, in terms of functionality, is capable of bidirectional scan, programmable integration time and 5 gain
settings at the input. Programming can be done parallel or serially with digital interface. ROIC can handle up to 3.5V
dynamic range with the input stage to be direct injection (DI) type. With the load being 10pF capacitive in parallel with
1MΩ resistance, output settling time is less than 250nsec enabling the clock frequency up to 4MHz. The manufacturing
technology is 0.35μm, double poly-Si, four-metal (3 metals and 1 top metal) 5V CMOS process.

/pdf/design-of-a-roic-for-scanning-type-hgcdte-lwir-focal-plane-27he5rxzby.pdf

Design of a ROIC for Scanning Type HgCdTe LWIR Focal Plane Arrays

This paper presents a novel and power efficient readout architecture for uncooled microbolometers that offers adequate noise performance along with a circuit-based method for self-heating compensation. The proposed method employs an event-generation scheme and a time-mode readout chain to achieve dynamic mode of operation resulting in low power. The readout chain consists of a capacitive transimpedance amplifier (CTIA) based current-to-time converter followed by a two stage time-to-digital converter (TDC). The CTIA employs a novel integration scheme for time amplification along with a modified reset mechanism to achieve self-heating compensation. We also present a model to analyze the implications of time-mode readout on imager operation. An experimental readout chip, based on this approach, has been designed using a 130 nm bulk CMOS technology. The proposed architecture offers robust frontend processing and achieves a per channel power consumption of $66~\mu \text{W}$ , which is considerably lower than the most recently reported designs, while maintaining better than 10-mK readout noise equivalent temperature difference (NETD).

Omer Ceylan

Papers

Wide Range, Process and Temperature Compensated Voltage Controlled Current Source

A new digital readout integrated circuit (DROIC) with pixel parallel A/D conversion and reduced quantization noise

A Phase-Calibration Method for Vector-Sum Phase Shifters Using a Self-Generated LUT

Design of a ROIC for Scanning Type HgCdTe LWIR Focal Plane Arrays

A Digital Readout IC for Microbolometer Imagers Offering Low Power and Improved Self-Heating Compensation