O
Orsolya Galamb
Researcher at Hungarian Academy of Sciences
Publications - 89
Citations - 1939
Orsolya Galamb is an academic researcher from Hungarian Academy of Sciences. The author has contributed to research in topics: Colorectal cancer & DNA methylation. The author has an hindex of 24, co-authored 85 publications receiving 1638 citations. Previous affiliations of Orsolya Galamb include Semmelweis University.
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Journal ArticleDOI
Inflammation, adenoma and cancer: objective classification of colon biopsy specimens with gene expression signature.
Orsolya Galamb,Balazs Gyorffy,Ferenc Sipos,Sándor Spisák,Anna Mária Németh,Pál Miheller,Zsolt Tulassay,Elek Dinya,Béla Molnár +8 more
TL;DR: Using routine biopsy samples, whole genomic microarray analysis was successfully performed to identify discriminative signatures and provide further insight into the pathophysiological background of colonic diseases.
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Epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions in the colon
Ferenc Sipos,Orsolya Galamb +1 more
TL;DR: A role for transforming growth factor-β and its downstream Smad signaling, the phosphatidylinositol 3'-kinase/Akt/mTOR axis, the Ras-mitogen-activated protein kinase/Snail/Slug and FOXC2 pathway, and Hedgehog signaling and microRNAs in the development of colorectal cancers via epithelial-to-mesenchymal transition are discussed.
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Colorectal adenoma and cancer detection based on altered methylation pattern of SFRP1, SFRP2, SDC2, and PRIMA1 in plasma samples
Barbara Kinga Barták,Alexandra Kalmár,Bálint Péterfia,Árpád V. Patai,Orsolya Galamb,Gábor Valcz,Sándor Spisák,Barnabás Wichmann,Zsófia Brigitta Nagy,Kinga Tóth,Zsolt Tulassay,Peter Igaz,Béla Molnár +12 more
TL;DR: A panel of biomarkers with altered methylation along the colorectal adenoma-carcinoma sequence in both colonic tissue and plasma is developed, suggesting that this methylation biomarker panel allows non-invasive detection of colorectors adenomas and cancer from plasma samples.
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Diagnostic mRNA expression patterns of inflamed, benign, and malignant colorectal biopsy specimen and their correlation with peripheral blood results
Orsolya Galamb,Ferenc Sipos,Norbert Solymosi,Sándor Spisák,Tibor Krenács,Kinga Tóth,Zsolt Tulassay,Béla Molnár +7 more
TL;DR: Whole genomic microarray analysis using routine biopsy samples is suitable for the identification of discriminative signatures for differential diagnostic purposes and may be the basis for new GEP-based diagnostic methods.
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Reversal of gene expression changes in the colorectal normal-adenoma pathway by NS398 selective COX2 inhibitor
Orsolya Galamb,Sándor Spisák,Sándor Spisák,Ferenc Sipos,Kinga Tóth,Norbert Solymosi,Barnabás Wichmann,Tibor Krenács,Gábor Valcz,Zsolt Tulassay,Zsolt Tulassay,Béla Molnár,Béla Molnár +12 more
TL;DR: N-(2-cyclohexyloxy-4-nitrophenyl)-methanesulfonamide has a reversal effect on the expression of several genes that altered in colorectal adenoma–carcinoma sequence, and more efficiently inverted the expression changes seen in the normal-adenoma than in thenormal-cARCinoma transition.