The importance of transition metals in biological processes has been well established. Copper (Cu) is a transition metal that can exist in oxidised and reduced states. This allows it to participate in redox and catalytic chemistry, making it a suitable cofactor for a diverse range of enzymes and molecules. Cu deficiency or toxicity is implicated in a variety of pathological conditions; therefore inorganic complexes of Cu have been investigated for their therapeutic and diagnostic potential. These Cu complexes have been shown to be effective in cancer treatment due to their cytotoxic action on tumour cells. Alternatively, Cu complexes can also modulate Cu homeostasis in the brain, resulting in protective effects in several models of neurodegeneration. In other diseases such as coronary heart disease and skin disease, the success of Cu complexes as potential therapeutics will most likely be due to their ability to increase SOD activity, leading to relief of oxidative stress. This review seeks to provide a broad insight into some of the diverse actions of Cu complexes and demonstrate the strong future for these compounds as potential therapeutic agents.

Copper complexes as therapeutic agents

III. Structures of Organic Polysulfanes 3922 A. General 3922 B. Structures of Chain-Like R−Sn−R Molecules 3923 C. Structures of Cyclic R−Sn−R Molecules 3924 D. Conformational Studies 3925 IV. Analysis of Organic Polysulfanes 3925 A. General 3925 B. NMR Spectroscopy 3926 C. Chromatography 3926 D. Raman Spectroscopy 3928 E. XANES Spectroscopy 3928 V. Reactions of Organic Polysulfanes 3928 A. Interconversion Reactions 3928 B. Sulfur Transfer Reactions 3930 C. Replacement Reactions 3931 D. Nucleophilic Displacement Reactions at the Sulfur−Sulfur Bond 3931

The chemistry of organic polysulfanes R-Sn-R (n > 2)

Catechol oxidase and phenoxazinone synthase: Biomimetic functional models and mechanistic studies

Metal complexes of saccharin

Although copper-ligand complexes appear to be promising as a new class of therapeutics, other than the family of copper(ii) coordination compounds referred to as casiopeinas these compounds have yet to reach the clinic for human use. The pharmaceutical challenges associated with developing copper-based therapeutics will be presented in this article along with a discussion of the potential for high-throughput chemistry, computer-aided drug design, and nanotechnology to address the development of this important class of drug candidates.

A Perspective – can copper complexes be developed as a novel class of therapeutics?

Therapeutic properties, SOD and catecholase mimetic activities of novel ternary copper(II) complexes of the anti-inflammatory drug Fenoprofen with imidazole and caffeine

Structural and spectroscopic characterization of two new Cd(II) complexes: bis(thiosaccharinato)bis(imidazole) cadmium(II) and tris(thiosaccharinato)aquacadmate(II)

Crystal Structure, Spectroscopic and Thermal Behaviour of Bis(saccharinato)tetrakis(pyridine)nickel(II) Dipyridine

Abstract The crystal structure of [Zn(sac)2(py)2] has been de termined by single-crystal X-ray diffractometry. It crystallizes in the monoclinic space group C2/c with Z = 4. We propose and discuss an assignment of its IR and Raman spectra, compatible with the structural characteristics. Its thermal behavior was investigated by means of TG and DTA methods. Some comparisons with related compounds are made.

Crystal structure, vibrational spectra and thermal analysis of bis(saccharinato)bis(pyridine)zinc(ii)

The aim of the present paper is to give structural information in order to set a correlation between the electrical conductivity behavior and structures of lithium and silver vanadium–tellurite based glasses. We report our structural studies and compare the effect of the nature of the metallic cation on glasses of the form XM2O · (1 − X)V2O5 · 2TeO2 (where 0 ⩽ X

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Oscar V. Quinzani

Papers

Therapeutic properties, SOD and catecholase mimetic activities of novel ternary copper(II) complexes of the anti-inflammatory drug Fenoprofen with imidazole and caffeine

Structural and spectroscopic characterization of two new Cd(II) complexes: bis(thiosaccharinato)bis(imidazole) cadmium(II) and tris(thiosaccharinato)aquacadmate(II)

Crystal Structure, Spectroscopic and Thermal Behaviour of Bis(saccharinato)tetrakis(pyridine)nickel(II) Dipyridine

Crystal structure, vibrational spectra and thermal analysis of bis(saccharinato)bis(pyridine)zinc(ii)

IR absorption spectra of lithium and silver vanadium–tellurite based glasses