抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Summary for policymakers Technical summary 1. The climate system - an overview 2. Observed climate variability and change 3. The carbon cycle and atmospheric CO2 4. Atmospheric chemistry and greenhouse gases 5. Aerosols, their direct and indirect effects 6. Radiative forcing of climate change 7. Physical climate processes and feedbacks 8. Model evaluation 9. Projections of future climate change 10. Regional climate simulation - evaluation and projections 11. Changes in sea level 12. Detection of climate change and attribution of causes 13. Climate scenario development 14. Advancing our understanding Glossary Index Appendix.

Climate change 2001: the scientific basis

Drafting Authors: Neil Adger, Pramod Aggarwal, Shardul Agrawala, Joseph Alcamo, Abdelkader Allali, Oleg Anisimov, Nigel Arnell, Michel Boko, Osvaldo Canziani, Timothy Carter, Gino Casassa, Ulisses Confalonieri, Rex Victor Cruz, Edmundo de Alba Alcaraz, William Easterling, Christopher Field, Andreas Fischlin, Blair Fitzharris, Carlos Gay García, Clair Hanson, Hideo Harasawa, Kevin Hennessy, Saleemul Huq, Roger Jones, Lucka Kajfež Bogataj, David Karoly, Richard Klein, Zbigniew Kundzewicz, Murari Lal, Rodel Lasco, Geoff Love, Xianfu Lu, Graciela Magrín, Luis José Mata, Roger McLean, Bettina Menne, Guy Midgley, Nobuo Mimura, Monirul Qader Mirza, José Moreno, Linda Mortsch, Isabelle Niang-Diop, Robert Nicholls, Béla Nováky, Leonard Nurse, Anthony Nyong, Michael Oppenheimer, Jean Palutikof, Martin Parry, Anand Patwardhan, Patricia Romero Lankao, Cynthia Rosenzweig, Stephen Schneider, Serguei Semenov, Joel Smith, John Stone, Jean-Pascal van Ypersele, David Vaughan, Coleen Vogel, Thomas Wilbanks, Poh Poh Wong, Shaohong Wu, Gary Yohe

Contribution of Working Group II to the Fourth Assessment Report of the Intergovernmental Panel on Climate Change

This paper describes the contents of the 2016 edition of the HITRAN molecular spectroscopic compilation. The new edition replaces the previous HITRAN edition of 2012 and its updates during the intervening years. The HITRAN molecular absorption compilation is composed of five major components: the traditional line-by-line spectroscopic parameters required for high-resolution radiative-transfer codes, infrared absorption cross-sections for molecules not yet amenable to representation in a line-by-line form, collision-induced absorption data, aerosol indices of refraction, and general tables such as partition sums that apply globally to the data. The new HITRAN is greatly extended in terms of accuracy, spectral coverage, additional absorption phenomena, added line-shape formalisms, and validity. Moreover, molecules, isotopologues, and perturbing gases have been added that address the issues of atmospheres beyond the Earth. Of considerable note, experimental IR cross-sections for almost 300 additional molecules important in different areas of atmospheric science have been added to the database. The compilation can be accessed through www.hitran.org. Most of the HITRAN data have now been cast into an underlying relational database structure that offers many advantages over the long-standing sequential text-based structure. The new structure empowers the user in many ways. It enables the incorporation of an extended set of fundamental parameters per transition, sophisticated line-shape formalisms, easy user-defined output formats, and very convenient searching, filtering, and plotting of data. A powerful application programming interface making use of structured query language (SQL) features for higher-level applications of HITRAN is also provided.

/pdf/the-hitran-2008-molecular-spectroscopic-database-1ud8clpej3.pdf

The HITRAN 2008 molecular spectroscopic database

A rapid and accurate radiative transfer model (RRTM) for climate applications has been developed and the results extensively evaluated. The current version of RRTM calculates fluxes and cooling rates for the longwave spectral region (10–3000 cm−1) for an arbitrary clear atmosphere. The molecular species treated in the model are water vapor, carbon dioxide, ozone, methane, nitrous oxide, and the common halocarbons. The radiative transfer in RRTM is performed using the correlated-k method: the k distributions are attained directly from the LBLRTM line-by-line model, which connects the absorption coefficients used by RRTM to high-resolution radiance validations done with observations. Refined methods have been developed for treating bands containing gases with overlapping absorption, for the determination of values of the Planck function appropriate for use in the correlated-k approach, and for the inclusion of minor absorbing species in a band. The flux and cooling rate results of RRTM are linked to measurement through the use of LBLRTM, which has been substantially validated with observations. Validations of RRTM using LBLRTM have been performed for the midlatitude summer, tropical, midlatitude winter, subarctic winter, and four atmospheres from the Spectral Radiance Experiment campaign. On the basis of these validations the longwave accuracy of RRTM for any atmosphere is as follows: 0.6 W m−2 (relative to LBLRTM) for net flux in each band at all altitudes, with a total (10–3000 cm−1) error of less than 1.0 W m−2 at any altitude; 0.07 K d−1 for total cooling rate error in the troposphere and lower stratosphere, and 0.75 K d−1 in the upper stratosphere and above. Other comparisons have been performed on RRTM using LBLRTM to gauge its sensitivity to changes in the abundance of specific species, including the halocarbons and carbon dioxide. The radiative forcing due to doubling the concentration of carbon dioxide is attained with an accuracy of 0.24 W m−2, an error of less than 5%. The speed of execution of RRTM compares favorably with that of other rapid radiation models, indicating that the model is suitable for use in general circulation models.

https://agupubs.onlinelibrary.wiley.com/doi/pdf/10.1029/97JD00237

Radiative transfer for inhomogeneous atmospheres: RRTM, a validated correlated-k model for the longwave

Multi-Decadal Global Cooling and Unprecedented Ozone Loss Following a Regional Nuclear Conflict

The tropospheric and stratospheric nitrate aerosol is simulated by a sectional aerosol model coupled to the Community Earth System Model. The simulated nitrate mass fractional contribution to aerosols is significantly higher in the upper troposphere and lower stratosphere (UTLS) than that at the surface. Both in situ measurements and simulations show that nitrate aerosol accounts for about 30%–40% of the aerosol mass at the tropopause of the Asian summer monsoon (ASM) region. Furthermore, simulated condensed nitric acid particles account for ∼20% of the annual mean aerosol mass at the tropical tropopause, and over 95% in the UTLS at the South Pole in June‐July‐August. Our study suggests that the extremely cold ambient conditions in the UTLS of the tropics, ASM and polar regions thermodynamically favor the condensation of ammonia and nitric acid. The widely distributed nitrate aerosol in the global UTLS may be overlooked by climate models.

Abundant Nitrate and Nitric Acid Aerosol in the Upper Troposphere and Lower Stratosphere

Publisher Summary
In this chapter, the potential impact of soot particles from aircraft exhaust on cirrus clouds is discussed. Soot particles injected directly in the upper troposphere by jet aircraft may act as heterogeneous ice nuclei. If the soot particles are sufficiently effective as ice nuclei, then they will allow ice nucleation at lower supersaturations than those required for homogeneous freezing of sulfate aerosols, resulting in an increase in the aerial coverage of cirrus clouds. Simulations using a detailed ice cloud model indicate that cirrus driven by synoptic-scale lifting are transient, precipitating clouds, if only pure sulfate haze aerosols are present. However, if effective heterogeneous nuclei are present, then extensive, persistent, diffuse cirrus should form. In addition, heterogeneous ice nucleation on soot particles may modify the number of ice crystals nucleated in cirrus, resulting in alterations of the cloud evolution and radiative properties. Parcel model simulations indicate that heterogeneous freezing on relatively few soot particles should result in fewer ice crystals nucleating. However, if large numbers of soot particles are present, the ice crystal number density may be increased.

The potential impact of soot particles from aircraft exhaust on cirrus clouds

The Atmospheric Temperature Structure of Titan.

In 1982, a northern British Columbia forest fire created a massive smoke plume that could be detected for several days in satellite imagery. The radiative and dynamical impacts of this large forest fire smoke plume are investigated using interactive prognostic models of atmospheric circulation, aerosol microphysics and transport, and radiative heat transfer.

Owen B. Toon

Papers

Multi-Decadal Global Cooling and Unprecedented Ozone Loss Following a Regional Nuclear Conflict

Abundant Nitrate and Nitric Acid Aerosol in the Upper Troposphere and Lower Stratosphere

The potential impact of soot particles from aircraft exhaust on cirrus clouds

The Atmospheric Temperature Structure of Titan.

Atmospheric effects of a Canadian forest fire smoke plume