P
P.E.J. van Erp
Researcher at Radboud University Nijmegen
Publications - 119
Citations - 2971
P.E.J. van Erp is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Psoriasis & Keratinocyte. The author has an hindex of 33, co-authored 119 publications receiving 2820 citations. Previous affiliations of P.E.J. van Erp include Radboud University Nijmegen Medical Centre.
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Journal ArticleDOI
Constitutive and Inducible Expression of SKALP/Elafin Provides Anti-Elastase Defense in Human Epithelia
Rk Pfundt,F. van Ruissen,I.M.J.J. van Vlijmen-Willems,Hans A. C. Alkemade,Patrick L.J.M. Zeeuwen,P. H. Jap,H.B.P.M. Dijkman,Jack A.M. Fransen,H.J.E. Croes,P.E.J. van Erp,J. Schalkwijk +10 more
TL;DR: It is shown that SKALP is constitutively expressed in several epithelia that are continuously subjected to inflammatory stimuli, such as the oral cavity and the vagina where it co-localizes with type 1 TGase, which strongly suggest that the constitutive expression ofSKALP in squamous epithelian, and the inducible expression in epidermis participate in the control of epithelial integrity, by inhibiting PMN derived proteinases.
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Pretreatment to enhance protoporphyrin IX accumulation in photodynamic therapy
TL;DR: Simple pretreatments or additions to the regular practice of PDT, aimed to optimize intralesional PpIX content, improve the clinical outcome.
Journal ArticleDOI
Memory effector (CD45RO+) and cytotoxic (CD8+) T cells appear early in the margin zone of spreading psoriatic lesions in contrast to cells expressing natural killer receptors, which appear late.
W.H.P.M. Vissers,C.H.M. Arndtz,L. Muys,P.E.J. van Erp,E.M.G.J. de Jong,P.C.M. van de Kerkhof +5 more
TL;DR: This data indicates that T‐lymphocyte subsets in particular activated effector memory T cells and natural killer T cells have been suggested to play an important role in the pathogenesis of psoriasis.
Journal Article
SKALP/elafin is an inducible proteinase inhibitor in human epidermal keratinocytes
J.A.C. Alkemade,H. O. F. Molhuizen,Maria Ponec,Johanna Kempenaar,Patrick L.J.M. Zeeuwen,G. J. de Jongh,I.M.J.J. van Vlijmen-Willems,P.E.J. van Erp,P.C.M. van de Kerkhof,J. Schalkwijk +9 more
TL;DR: The induction and processing of SKALP in vivo and in vitro is reported and it is found that in a submerged culture system,SKALP could be induced by fetal calf serum and in cultured cells was found to be dependent on the system used.
Journal ArticleDOI
Molecular diagnostics of psoriasis, atopic dermatitis, allergic contact dermatitis and irritant contact dermatitis
Marijke Kamsteeg,Patrick A. M. Jansen,I.M.J.J. van Vlijmen-Willems,P.E.J. van Erp,Diana Rodijk-Olthuis,P.G.M. van der Valk,Ton Feuth,Patrick L.J.M. Zeeuwen,Joost Schalkwijk +8 more
TL;DR: Microarray studies on the epidermal transcriptome in psoriasis and atopic dermatitis have revealed genes with disease‐specific expression in keratinocytes of lesional epidermis that could provide a tool for molecular diagnostics of inflammatory skin conditions in general.