J
Joost Schalkwijk
Researcher at Radboud University Nijmegen
Publications - 233
Citations - 13937
Joost Schalkwijk is an academic researcher from Radboud University Nijmegen. The author has contributed to research in topics: Psoriasis & Keratinocyte. The author has an hindex of 57, co-authored 223 publications receiving 12417 citations. Previous affiliations of Joost Schalkwijk include Utrecht University & Hospital Sant Joan de Déu Barcelona.
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Journal ArticleDOI
A Genome-Wide Association Study Identifies New Psoriasis Susceptibility Loci and an Interaction Between HLA-C and ERAP1
Amy Strange,Francesca Capon,Chris C. A. Spencer,Jo Knight,Michael E. Weale,Michael H. Allen,Anne Barton,Gavin Band,Céline Bellenguez,Judith G.M. Bergboer,Jenefer M. Blackwell,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Michael J. Cork,Aiden Corvin,Panos Deloukas,Alexander T. Dilthey,Audrey Duncanson,Sarah Edkins,Xavier Estivill,Oliver FitzGerald,Colin Freeman,Emiliano Giardina,Emma Gray,Angelika Hofer,Ulrike Hüffmeier,Sarah E. Hunt,Alan D. Irvine,Janusz Jankowski,Brian Kirby,Cordelia Langford,Jesús Lascorz,Joyce Leman,Stephen Leslie,Lotus Mallbris,Hugh S. Markus,Christopher G. Mathew,W.H. Irwin McLean,Ross McManus,Rotraut Mössner,Loukas Moutsianas,Åsa Torinsson Naluai,Frank O. Nestle,Giuseppe Novelli,Alexandros Onoufriadis,Colin N. A. Palmer,Carlo Perricone,Matti Pirinen,Robert Plomin,Simon C. Potter,Ramon M. Pujol,Anna Rautanen,Eva Riveira-Muñoz,Anthony W. Ryan,Wolfgang Salmhofer,Lena Samuelsson,Stephen Sawcer,Joost Schalkwijk,Catherine H. Smith,Mona Ståhle,Zhan Su,Rachid Tazi-Ahnini,Heiko Traupe,Ananth C. Viswanathan,Ananth C. Viswanathan,Richard B. Warren,Wolfgang Weger,Katarina Wolk,Nicholas W. Wood,Jane Worthington,Helen S. Young,Patrick L.J.M. Zeeuwen,Adrian Hayday,A. David Burden,Christopher E.M. Griffiths,Juha Kere,André Reis,Gilean McVean,David M. Evans,Matthew A. Brown,Jonathan Barker,Leena Peltonen,Peter Donnelly,Peter Donnelly,Richard C. Trembath +85 more
TL;DR: These findings implicate pathways that integrate epidermal barrier dysfunction with innate and adaptive immune dysregulation in psoriasis pathogenesis and report compelling evidence for an interaction between the HLA-C and ERAP1 loci.
Journal ArticleDOI
Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity
Lam C. Tsoi,Sarah L. Spain,Sarah L. Spain,Jo Knight,Eva Ellinghaus,Eva Ellinghaus,Philip E. Stuart,Francesca Capon,Jun Ding,Yanming Li,Trilokraj Tejasvi,Johann E. Gudjonsson,Hyun Min Kang,Michael H. Allen,Ross McManus,Giuseppe Novelli,Lena Samuelsson,Joost Schalkwijk,Mona Ståhle,A. David Burden,Catherine H. Smith,Michael J. Cork,Xavier Estivill,Anne M. Bowcock,Gerald G. Krueger,Wolfgang Weger,Jane Worthington,Rachid Tazi-Ahnini,Frank O. Nestle,Adrian Hayday,Per Hoffmann,Juliane Winkelmann,Cisca Wijmenga,Cordelia Langford,Sarah Edkins,Robert Andrews,Hannah Blackburn,Amy Strange,Gavin Band,Richard D. Pearson,Damjan Vukcevic,Chris C. A. Spencer,Panos Deloukas,Ulrich Mrowietz,Stefan Schreiber,Stephan Weidinger,Sulev Kõks,Külli Kingo,Tõnu Esko,Andres Metspalu,Henry W. Lim,John J. Voorhees,Michael Weichenthal,H.-Erich Wichmann,Vinod Chandran,Cheryl F. Rosen,Proton Rahman,Dafna D. Gladman,Christopher E.M. Griffiths,André Reis,Juha Kere,Juha Kere,Rajan P. Nnair,Andre Franke,Jonathan Nn Barker,Ggoncalo R. Abecasis,James Tt Eelder,Richard Ttrembath,Richard Ttrembath,Kristina Callis Duffin,Cindy Helms,David E. Goldgar,Yun Li,Justin Paschall,Justin Paschall,Mary J. Malloy,Mary J. Malloy,Clive R. Pullinger,Clive R. Pullinger,John P. Kane,John P. Kane,Jennifer M. Gardner,Amy Perlmutter,Andrew Miner,Bing Jian Feng,Ravi Hiremagalore,Robert W. Ike,Enno Christophers,Tilo Henseler,Andreas Ruether,Steven J. Schrodi,Sampath Prahalad,Sampath Prahalad,Stephen L. Guthery,Stephen L. Guthery,Judith Fischer,Wilson Liao,Pui Kwok,Alan Menter,G. Mark Lathrop,Carol Wise,Ann B. Begovich,Alexandros Onoufriadis,Michael E. Weale,Angelika Hofer,Wolfgang Salmhofer,Peter Wolf,Kati Kainu,Ulpu Saarialho-Kere,Sari Suomela,Petra Badorf,Ulrike Hüffmeier,Werner Kurrat,Wolfgang Küster,Jesús Lascorz,Rotraut Mössner,Funda Schürmeier-Horst,Markward Ständer,Heiko Traupe,Judith G.M. Bergboer,Martin den Heijer,Martin den Heijer,Peter C.M. van de Kerkhof,Patrick L.J.M. Zeeuwen,L. Barnes,Linda E. Campbell,Caitriona Cusack,Ciara Coleman,Judith Conroy,Sean Ennis,Oliver FitzGerald,Phil Gallagher,Alan D. Irvine,Brian Kirby,Trevor Markham,W.H. Irwin McLean,Joe McPartlin,Sarah Rogers,Anthony W. Ryan,Agnieszka Zawirska,Emiliano Giardina,Tiziana Lepre,Carlo Perricone,Gemma Martin-Ezquerra,Ramon M. Pujol,Eva Riveira-Muñoz,Annica Inerot,Åsa Torinsson Naluai,Lotus Mallbris,Katarina Wolk,Joyce Leman,Anne Barton,Richard B. Warren,Helen S. Young,Isis Ricaño-Ponce,Gosia Trynka,Fawnda Pellett,Andrew Henschel,Marin Aurand,Bruce F. Bebo,Christian Gieger,Thomas Illig,Susanne Moebus,Karl-Heinz Jöckel,Raimund Erbel,Peter Donnelly,Peter Donnelly,Leena Peltonen,Jenefer M. Blackwell,Elvira Bramon,Elvira Bramon,Matthew A. Brown,Juan P. Casas,Aiden Corvin,Nicholas Craddock,Audrey Duncanson,Janusz Jankowski,Hugh S. Markus,Christopher G. Mathew,Mark I. McCarthy,Colin N. A. Palmer,Robert Plomin,Anna Rautanen,Stephen J. Sawcer,Nilesh J. Samani,Ananth C. Viswanathan,Nicholas W. Wood,Céline Bellenguez,Colin Freeman,Garrett Hellenthal,Eleni Giannoulatou,Matti Pirinen,Zhan Su,Sarah E. Hunt,Rhian Gwilliam,Suzannah Bumpstead,Serge Dronov,Matthew W. Gillman,Emma Gray,Naomi Hammond,Alagurevathi Jayakumar,O. T. McCann,Jennifer Liddle,M. Perez,Simon C. Potter,Radhi Ravindrarajah,Michelle Ricketts,Matthew Waller,Paul A. Weston,Sara Widaa,Pamela Whittaker,Rajan P. Neir,Jonathan Barker,Gonçalo R. Abecasis,James T. Elder,Richard C. Trembath +215 more
TL;DR: A meta-analysis of genome-wide association studies and independent data sets genotyped on the Immunochip identified 15 new susceptibility loci, increasing to 36 the number associated with psoriasis in European individuals, and identified five independent signals within previously known loci.
A genome-wide asociation study identifies new psoriasis susceptibility loci and an interaction betwEn HLA-C and ERAP1
A. Strange,Francesca Capon,C. C. A. Spencer,Joanne Knight,Michael E. Weale,Michael H. Allen,Anne Barton,Céline Bellenguez,Judith G.M. Bergboer,J. M. BlackweL,Elvira Bramon,Suzannah Bumpstead,Juan P. Casas,Michael J. Cork,Aiden Corvin,Panagiotis Deloukas,Alexander T. Dilthey,Audrey Duncanson,Sarah Edkins,X. EstiviL,Oliver FitzGerald,C. FrEman,Emiliano Giardina,Emma Gray,Angelika Hofer,Ulrike Hüffmeier,Sarah E. Hunt,Alan D. Irvine,Janusz Jankowski,Brian Kirby,Cordelia Langford,Jesús Lascorz,Joyce Leman,Stephen Leslie,L. MaLbris,Hugh S. Markus,Christopher G. Mathew,Whi McLean,Ross McManus,R. MöSner,Loukas Moutsianas,Åsa Torinsson Naluai,Frank O. Nestle,G. NoveLi,Alexandros Onoufriadis,Colin N. A. Palmer,Carlo Perricone,Matti Pirinen,Robert Plomin,S. C. PoTer,Ramon M. Pujol,Anna Rautanen,Eva Riveira-Muñoz,Anthony W. Ryan,Wolfgang Salmhofer,L. SamuelSon,Stephen Sawcer,Joost Schalkwijk,Catherine H. Smith,Mona Ståhle,Zhan Su,Rachid Tazi-Ahnini,Heiko Traupe,Ananth C. Viswanathan,Richard B. Warren,Wolfgang Weger,Katarina Wolk,N. Wod,Jane Worthington,Helen S. Young,Patrick L.J.M. Zeeuwen,Adrian Hayday,A D Burden,Christopher E.M. Griffiths,Juha Kere,André Reis,Gil McVean,David M. Evans,Matthew A. Brown,J. Barker,Leena Peltonen,P. Donely,Richard C. Trembath +82 more
TL;DR: In this article, a genome-wide asociation study of 594,224 SNPs in 2,622 individuals with psoriasis and 5,667 controls was conducted.
Journal ArticleDOI
Psoriasis is associated with increased beta-defensin genomic copy number.
Edward J. Hollox,Ulrike Hüffmeier,Patrick L.J.M. Zeeuwen,Raquel Palla,Jesús Lascorz,Diana Rodijk-Olthuis,Peter C.M. van de Kerkhof,Heiko Traupe,Gys J. de Jongh,Martin den Heijer,André Reis,John A.L. Armour,Joost Schalkwijk +12 more
TL;DR: Comparisons in both cohorts showed a significant association between higher genomic copy number for β-defensin genes and risk of psoriasis.
Journal ArticleDOI
Deletion of the late cornified envelope LCE3B and LCE3C genes as a susceptibility factor for psoriasis
Rafael de Cid,Eva Riveira-Muñoz,Patrick L.J.M. Zeeuwen,Jason Robarge,Wilson Liao,Emma N. Dannhauser,Emiliano Giardina,Philip E. Stuart,Rajan P. Nair,Cynthia Helms,Geòrgia Escaramís,Ester Ballana,Gemma Martin-Ezquerra,Martin den Heijer,Marijke Kamsteeg,Irma Joosten,Evan E. Eichler,Conxi Lázaro,Ramon M. Pujol,Lluís Armengol,Gonçalo R. Abecasis,James T. Elder,Giuseppe Novelli,John A.L. Armour,Pui-Yan Kwok,Anne M. Bowcock,Joost Schalkwijk,Xavier Estivill +27 more
TL;DR: LCE expression can be induced in normal epidermis by skin barrier disruption and is strongly expressed in psoriatic lesions, suggesting that compromised skin barrier function has a role in psoriasis susceptibility.