P
P. Elizabeth Rakoczy
Researcher at University of Western Australia
Publications - 42
Citations - 1655
P. Elizabeth Rakoczy is an academic researcher from University of Western Australia. The author has contributed to research in topics: Vascular endothelial growth factor & Retina. The author has an hindex of 18, co-authored 42 publications receiving 1597 citations. Previous affiliations of P. Elizabeth Rakoczy include Lions Eye Institute.
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Journal ArticleDOI
Differentiation of marrow stromal cells into photoreceptors in the rat eye
Anthony Kicic,Weiyong Shen,Ann S Wilson,Ian J. Constable,Terry Robertson,P. Elizabeth Rakoczy +5 more
TL;DR: This study demonstrates for the first time the partial differentiation of adult CD90+ MSCs into photoreceptors in vitro and in vivo, and establishes that transplanted cells can attract synaptic vesicles and hence are potentially capable of signal transduction.
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Functional and structural recovery of the retina after gene therapy in the RPE65 null mutation dog.
Kristina Narfström,Martin L. Katz,Ragnheidur Bragadottir,Mathias W. Seeliger,Ana Boulanger,T. Michael Redmond,Lynette Caro,Chooi-May Lai,P. Elizabeth Rakoczy +8 more
TL;DR: In 10 of 11 treated RPE65(-/-) eyes, gene transfer resulted in development of vision, both subjectively apparent by loss of nystagmus, and objectively recorded by ERG.
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Adenovirus and adeno-associated virus vectors
TL;DR: Further development and vector improvements that continue to extend the utility of these vectors are discussed, such as cell retargeting by capsid modification, differential transduction by use of serotypes, and extension of the cloning capacity of rAAV vectors by dual vector heterodimerization.
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Mouse models of age-related macular degeneration
P. Elizabeth Rakoczy,Meaghan J.T. Yu,Meaghan J.T. Yu,Steven Nusinowitz,Bo Chang,John R. Heckenlively +5 more
TL;DR: This review aims to provide a framework for better understanding some of the existing animal models and the knowledge that has been derived from their evaluations, and to give basic physiology and visual processing genetics relevant to human AMD.
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Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide.
Robert J. Marano,Norbert Wimmer,Philip Kearns,Bradley G. Thomas,Istvan Toth,M. Brankov,P. Elizabeth Rakoczy +6 more
TL;DR: It is demonstrated that lipophilic, charged dendrimer mediated delivery of ODN-1 resulted in the down-regulation of in vitro VEGF expression, indicating protection of ODn-1 from the effects of endogenous nucleases.