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Norbert Wimmer
Researcher at University of Queensland
Publications - 34
Citations - 747
Norbert Wimmer is an academic researcher from University of Queensland. The author has contributed to research in topics: Heparan sulfate & Disaccharide. The author has an hindex of 11, co-authored 31 publications receiving 679 citations. Previous affiliations of Norbert Wimmer include University of Agricultural Sciences, Dharwad & Australian National University.
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Journal ArticleDOI
Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity
TL;DR: The use of a lipophilic amino-acid dendrimer to deliver an anti-vascular endothelial growth factor (VEGF) oligonucleotide (ODN-1) into the eyes of rats and inhibit laser-induced choroidal neovascularization (CNV) is concluded.
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Discovery of PG545: A Highly Potent and Simultaneous Inhibitor of Angiogenesis, Tumor Growth, and Metastasis
Vitto Ferro,Ligong Liu,Ken D. Johnstone,Norbert Wimmer,Tomislav Karoli,Paul Handley,Jessica Rowley,Keith Dredge,Cai Ping Li,Edward Hammond,Kat Davis,Laura Jane Sarimaa,Job Harenberg,Ian Bytheway +13 more
TL;DR: Increasing the aglycone lipophilicity of a series of polysulfated oligosaccharide glycoside heparan sulfate (HS) mimetics via attachment of a steroid or long chain alkyl group resulted in compounds with significantly improved in vitro and ex vivo antiangiogenic activity.
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Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide.
Robert J. Marano,Norbert Wimmer,Philip Kearns,Bradley G. Thomas,Istvan Toth,M. Brankov,P. Elizabeth Rakoczy +6 more
TL;DR: It is demonstrated that lipophilic, charged dendrimer mediated delivery of ODN-1 resulted in the down-regulation of in vitro VEGF expression, indicating protection of ODn-1 from the effects of endogenous nucleases.
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The PG500 series: novel heparan sulfate mimetics as potent angiogenesis and heparanase inhibitors for cancer therapy
Keith Dredge,Edward Hammond,Kat Davis,Cai Ping Li,Ligong Liu,Ken D. Johnstone,Paul Handley,Norbert Wimmer,Thomas J. Gonda,Anand Gautam,Vito Ferro,Ian Bytheway +11 more
TL;DR: PG545 has been selected as the lead clinical candidate for oncology and is currently undergoing formal preclinical development as a novel treatment for advanced cancer.
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Syntheses of polycationic dendrimers on lipophilic peptide core for complexation and transport of oligonucleotides.
TL;DR: Synthesis of novel polycationic lipophilic peptide core(s) was accomplished and these agents successfully transfected human retinal pigment epithelium cells with ODN1 upon complexation with the oligonucleotide.