P Goodfellow

TL;DR: It is shown that the human equivalents of c-fes and c-abl are localized on human chromosomes 15 and 9, respectively, and this findings exclude the possibility that these transformation-related genes are clustered at a single locus within the human genome.

TL;DR: Human fibroblasts containing a translocation between the X chromosome and chromosome 15 were fused with the 6-thioguanine-resistant mouse cell line, IR, and hybrids, selected in HAT medium, retained the X/15 chromosome.

TL;DR: The Ir genetic region of the mouse has been shown to contain genes controlling a new set of serological specificities called Ia for immune associated, which has a tissue distribution that often does not include T lymphocytes.

TL;DR: This interpretation is based on the following arguments: that the antigens solubilised from guinea pig and human tissues by sonication and 3 M KCl extraction have been reported to be non-glycosylated, which would be explicable if the latter procedures had caused degradation and the consequent separation of the carbohydrate from the molecule bearing the antigenic determinant.

TL;DR: Human Ia antigens were extensively purified (1390‐fold increase in specific activity) in 32% yield from BRI8 cells, a lymphoblastoid B‐cell line, and were determined by the polypeptide structure.