Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group

International consensus report on the investigation and management of primary immune thrombocytopenia.

https://pedclerk.uchicago.edu/sites/pedclerk.uchicago.edu/files/uploads/Blood-2011-Neunert-4190-207%281%29.pdf

The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.

Immune thrombocytopenic purpura, which may lead to bleeding, is typically caused by antibodies directed against the platelet glycoprotein IIb/IIIa complex. Since the management of the disorder is different for children and adults, the authors of this up-to-date review provide separate sections on the two age groups. Along with advances in management, they also discuss the current understanding of pathophysiology and, in particular, the way in which autoantibodies against platelets are generated.

Immune thrombocytopenic purpura.

https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(08)60203-2.pdf

Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial

http://www.ouhsc.edu/platelets/////ITP/ITP%20Publications/pub2_1.pdf

Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

The pathophysiology of HIV associated immune thrombocytopenia (HIV-ITP) and its response to AZT was investigated. Using autologous 111Indium-labelled platelets, platelet kinetic were analysed in two patient groups. Group 1 (untreated) was comprised of 13 patients with HIV-ITP. Group 2 (AZT) was comprised of 6 patients with a history of HIV-ITP prior to starting AZT. These patients were studied following a rise in their platelet count on AZT. Platelet survivals in both groups were shortened compared to controls, however there was no significant difference between the 2 groups. However platelet turnover rates were significantly depressed in Group 1 compared to Group 2 (P<0.05) and control values (P<0.05). The platelet count correlated with platelet turnover in Group 1 but not in AZT treated patients. Thus patients with HIV-ITP appear to have both shortened survivals and suppressed platelet production. The mechanism of the latter is unknown, but the increased turnover rate seen with AZT suggests it is a direct or indirect effect of the HIV virus.

Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men. A preliminary report.

Management of ITP during pregnancy is controversial. In a review of management options it is important to distinguish between intervention that is directed at the well-being of the fetus and therapy that is initiated for maternal reasons alone

P. J. Ballem

Papers

Idiopathic thrombocytopenic purpura: a practice guideline developed by explicit methods for the American Society of Hematology.

Pathophysiology of thrombocytopenia associated with HIV infection in homosexual men. A preliminary report.

Commentary on the management of autoimmune thrombocytopenia during pregnancy and in the neonatal period.