P
P. Nanjappan
Researcher at Bristol-Myers Squibb
Publications - 10
Citations - 116
P. Nanjappan is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Ligand (biochemistry) & Alkylation. The author has an hindex of 4, co-authored 10 publications receiving 112 citations.
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Journal ArticleDOI
A distinct strategy to generate high-affinity peptide binders to receptor tyrosine kinases
A. Shrivastava,M.A. von Wronski,Aaron K. Sato,Daniel T. Dransfield,Daniel J. Sexton,Nancy J. Bogdan,Radhakrishna Pillai,P. Nanjappan,Bo Song,E. Marinelli,Daniel B. DeOliveira,C. Luneau,Mary Devlin,A. Muruganandam,A. Abujoub,G. Connelly,Q.L. Wu,Greg Conley,Q. Chang,Michael F. Tweedle,Robert C. Ladner,Rolf E Swenson,Adrian D. Nunn +22 more
TL;DR: A novel and general way of generating high affinity peptide (HAP) binders to receptor tyrosine kinases (RTKs) using a multi-step process comprising phage-display selection, identification of peptide pairs suitable for hetero-dimerization and chemical synthesis of heterodimers is described.
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An efficient synthesis of some 6-substituted 4,8-diaza-3,3,9,9- tetramethylundeca-2,10-dione dioximes (propylene amine oximes, PnAOs): Ligands for 99mTc complexes used in structure distribution relationship (SDR) studies
TL;DR: In this paper, an alternative approach of the synthesis of PnAO was developed, which involved the alkylation of the propylenediamine with 3-bromo-3-methylbutan-2-one followed by oximation of the resulting diamine-diketone.
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Boronic acid adducts of technetium dioxime (BATO) complexes derived from quinuclidine benzilate (QNB) boronic acid stereoisomers: Syntheses and studies of their binding to the muscarinic acetylcholine receptor
Silvia S. Jurisson,Pirro John P,Richard J. DiRocco,Karen C. Rosenspire,Elaine Jagoda,P. Nanjappan,William C. Eckelman,David P. Nowotnik,Adrian D. Nunn +8 more
TL;DR: The interaction between the TcCl(DMG)3B-QNB complexes and biological membranes is dominated by the hydrophobicity of the BATO moiety, which has little potential for mAChR imaging.
Journal ArticleDOI
Synthesis of Functionalized 3,3,9,9-Tetramethyl-4,8-Diazaundecane-2,10-Dione Dioximes (Propylene Amine Oximes, PnAOs)
TL;DR: In this paper, the synthesis of several new derivatives of PnAO and their chloronitroso precursors are described and an unexpected product, an isooxalone, was formed while attempting to prepare 1-carbomethoxyl-PnAOs.
Journal ArticleDOI
Separation of the Stereoisomers of Hexamethyl-Propyleneamine Oxime (HM-PAO) by High-Performance Liquid Chromatography
TL;DR: The Resolvosil BSA-7, Chiracel OD, and Chiralpak AD columns were examined to determine whether one might be suitable for the separation of enatiomers of the ligand hexamethyl-propyleneamine oxime (HM-PAO) and/or its technetium-99m complex as mentioned in this paper.