抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

/pdf/surface-plasmon-subwavelength-optics-5e55p12p4o.pdf

Surface plasmon subwavelength optics

We review the field of cavity optomechanics, which explores the interaction between electromagnetic radiation and nano- or micromechanical motion This review covers the basics of optical cavities and mechanical resonators, their mutual optomechanical interaction mediated by the radiation pressure force, the large variety of experimental systems which exhibit this interaction, optical measurements of mechanical motion, dynamical backaction amplification and cooling, nonlinear dynamics, multimode optomechanics, and proposals for future cavity quantum optomechanics experiments In addition, we describe the perspectives for fundamental quantum physics and for possible applications of optomechanical devices

Cavity Optomechanics

Photonic crystal fibers guide light by corralling it within a periodic array of microscopic air holes that run along the entire fiber length Largely through their ability to overcome the limitations of conventional fiber optics—for example, by permitting low-loss guidance of light in a hollow core—these fibers are proving to have a multitude of important technological and scientific applications spanning many disciplines The result has been a renaissance of interest in optical fibers and their uses

https://science.sciencemag.org/content/sci/299/5605/358.full.pdf

Photonic crystal fibers

A fast-Fourier-transform method of topography and interferometry is proposed. By computer processing of a noncontour type of fringe pattern, automatic discrimination is achieved between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour-generation techniques. The method has advantages over moire topography and conventional fringe-contour interferometry in both accuracy and sensitivity. Unlike fringe-scanning techniques, the method is easy to apply because it uses no moving components.

Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry

We report the fabrication of a new type of optical waveguide: the photonic crystal fiber. It consists of a pure silica core surrounded by a silica-air photonic crystal material with a hexagonal symmetry. The fiber supports a single robust low-loss guided mode over a very broad spectral range of at least 458-1550 nm. Also see errata - http://eprints.soton.ac.uk/78010/

All-silica single-mode optical fiber with photonic crystal cladding

The confinement of light within a hollow core (a large air hole) in a silica-air photonic crystal fiber is demonstrated Only certain wavelength bands are confined and guided down the fiber, each band corresponding to the presence of a full two-dimensional band gap in the photonic crystal cladding Single-mode vacuum waveguides have a multitude of potential applications from ultrahigh-power transmission to the guiding of cold atoms

https://science.sciencemag.org/content/sci/285/5433/1537.full.pdf

Single-Mode Photonic Band Gap Guidance of Light in Air.

The history, fabrication, theory, numerical modeling, optical properties, guidance mechanisms, and applications of photonic-crystal fibers are reviewed

Photonic-Crystal Fibers

A fundamentally different type of optical waveguide structure is demonstrated, in which light is confined to the vicinity of a low-index region by a two-dimensional photonic band gap crystal. The waveguide consists of an extra air hole in an otherwise regular honeycomb pattern of holes running down the length of a fine silica glass fiber. Optical fibers based on this waveguide mechanism support guided modes with extraordinary properties.

https://science.sciencemag.org/content/sci/282/5393/1476.full.pdf

Photonic Band Gap Guidance in Optical Fibers

We have used the frequency comb generated by a femtosecond mode-locked laser and broadened to more than an optical octave in a photonic crystal fiber to realize a frequency chain that links a 10 MHz radio frequency reference phase-coherently in one step to the optical region. By comparison with a similar frequency chain we set an upper limit for the uncertainty of this new approach to 5. 1x10(-16). This opens the door for measurement and synthesis of virtually any optical frequency and is ready to revolutionize frequency metrology.

P. St. J. Russell

Papers

All-silica single-mode optical fiber with photonic crystal cladding

Single-Mode Photonic Band Gap Guidance of Light in Air.

Photonic-Crystal Fibers

Photonic Band Gap Guidance in Optical Fibers

Optical frequency synthesizer for precision spectroscopy