抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Surface plasmons are waves that propagate along the surface of a conductor. By altering the structure of a metal's surface, the properties of surface plasmons--in particular their interaction with light--can be tailored, which offers the potential for developing new types of photonic device. This could lead to miniaturized photonic circuits with length scales that are much smaller than those currently achieved. Surface plasmons are being explored for their potential in subwavelength optics, data storage, light generation, microscopy and bio-photonics.

/pdf/surface-plasmon-subwavelength-optics-5e55p12p4o.pdf

Surface plasmon subwavelength optics

We review the field of cavity optomechanics, which explores the interaction between electromagnetic radiation and nano- or micromechanical motion This review covers the basics of optical cavities and mechanical resonators, their mutual optomechanical interaction mediated by the radiation pressure force, the large variety of experimental systems which exhibit this interaction, optical measurements of mechanical motion, dynamical backaction amplification and cooling, nonlinear dynamics, multimode optomechanics, and proposals for future cavity quantum optomechanics experiments In addition, we describe the perspectives for fundamental quantum physics and for possible applications of optomechanical devices

Cavity Optomechanics

Photonic crystal fibers guide light by corralling it within a periodic array of microscopic air holes that run along the entire fiber length Largely through their ability to overcome the limitations of conventional fiber optics—for example, by permitting low-loss guidance of light in a hollow core—these fibers are proving to have a multitude of important technological and scientific applications spanning many disciplines The result has been a renaissance of interest in optical fibers and their uses

https://science.sciencemag.org/content/sci/299/5605/358.full.pdf

Photonic crystal fibers

A fast-Fourier-transform method of topography and interferometry is proposed. By computer processing of a noncontour type of fringe pattern, automatic discrimination is achieved between elevation and depression of the object or wave-front form, which has not been possible by the fringe-contour-generation techniques. The method has advantages over moire topography and conventional fringe-contour interferometry in both accuracy and sensitivity. Unlike fringe-scanning techniques, the method is easy to apply because it uses no moving components.

Fourier-transform method of fringe-pattern analysis for computer-based topography and interferometry

The dispersion of picosecond pulses on reflection from efficient photorefractive fiber gratings is explored experimentally. Unlike simple measurements of reflectivity, this approach allows both the amplitude and the phase of the grating response to be probed as a function of frequency.

Experimental investigation of picosecond pulse reflection from fiber gratings

We report an irradiation sensor based on a fluorescent “flying particle” that is optically trapped and propelled inside the core of a water-filled hollow-core photonic crystal fiber. When the moving particle passes through an irradiated region, its emitted fluorescence is captured by guided modes of the fiber core and so can be monitored using a filtered photodiode placed at the fiber end. The particle speed and position can be precisely monitored using in-fiber Doppler velocimetry, allowing the irradiation profile to be measured to a spatial resolution of ∼10 μm. The spectral response can be readily adjusted by appropriate choice of particle material. Using dye-doped polystyrene particles, we demonstrate detection of green (532 nm) and ultraviolet (340 nm) light.

/pdf/fluorescence-based-remote-irradiation-sensor-in-liquid-1b5bonpkm5.pdf

Fluorescence-based remote irradiation sensor in liquid-filled hollow-core photonic crystal fiber

Summary form only given. We have observed ultra-broad supercontinuum generation in a conventional telecommunications optical fibre (cutoff wavelength ~1250 nm, NA = 0.1). The fibre was tapered (heated and stretched in a flame) to reduce its diameter to 1.8 μm uniformly over a 90 mm length, without significant loss. Pulses (200-500 fs) from a Ti:sapphire laser tuned to 850 nm were launched into the fibre. The output spectrum for a pulse energy of 3.2nJ, corresponding to 240 mW average power, is plotted. Our tapered fibres (mounted in simple dustproof housings) were robust, surviving several days without degradation. We therefore anticipate that tapered fibres will be effective hosts for a number of other nonlinear effects also.

A generation of an ultra-broad supercontinuum in tapered fibres

A strong anti-Stokes Raman signal, from the vibrational Q(1) transition of hydrogen, is generated in gas-filled hollow-core photonic crystal fiber. To be efficient, this process requires phase-matching, which is not automatically provided since the group velocity dispersion is typically non-zero and—inside a fiber—cannot be compensated for using a crossed-beam geometry. Phase-matching can however be arranged by exploiting the different dispersion profiles of higher-order modes. We demonstrate the generation of first and second anti-Stokes signals in higher-order modes by pumping with an appropriate mixture of fundamental and a higher-order modes, synthesized using a spatial light modulator. Conversion efficiencies as high as 5.3% are achieved from the pump to the first anti-Stokes band.

Efficient anti-Stokes generation via intermodal stimulated Raman scattering in gas-filled hollow-core PCF.

The behavior of electromagnetic waves in chirally twisted structures is a topic of enduring interest, dating back at least to the 1940s invention of the microwave travelling-wave-tube amplifier and culminating in contemporary studies of chiral metamaterials, metasurfaces, and photonic crystal fibers (PCFs). Optical fibers with chiral microstructures, drawn from a spinning preform, have many useful properties, exhibiting, for example, circular birefringence and circular dichroism. It has recently been shown that chiral fibers with N-fold rotationally symmetric (symmetry group CN) transverse microstructures support families of helical Bloch modes (HBMs), each of which consists of a superposition of azimuthal Bloch harmonics (or optical vortices). An example is a fiber with N coupled cores arranged in a ring around its central axis (N-core single-ring fiber). Although this type of fiber can be readily modeled using scalar coupled-mode theory, a full description of its optical properties requires a vectorial analysis that takes account of the polarization state of the light, which is particularly important in studies of circular and vortical birefringence. In this paper, we develop, using an orthogonal 2D helicoidal coordinate system embedded in a cylindrical surface at constant radius, a rigorous vector coupled-mode description of the fields using local Frenet–Serret frames that rotate and twist with each of the N cores. The analysis places on a firm theoretical footing a previous HBM theory in which a heuristic approach was taken, based on physical intuition of the properties of Bloch waves. After a detailed review of the polarization evolution in a single spiraling core, analysis of the N-core single-ring system is carefully developed step by step. Accuracy limits of the analysis are assessed by comparison with the results of finite element modeling, focusing in particular on the dispersion, polarization states, and transverse field profiles of the HBMs. We believe this study provides clarity into what can sometimes be a rather difficult field and will facilitate further exploration of real-world applications of these fascinating waveguiding systems.

P. St. J. Russell

Papers

Experimental investigation of picosecond pulse reflection from fiber gratings

Fluorescence-based remote irradiation sensor in liquid-filled hollow-core photonic crystal fiber

A generation of an ultra-broad supercontinuum in tapered fibres

Efficient anti-Stokes generation via intermodal stimulated Raman scattering in gas-filled hollow-core PCF.

Frenet–Serret analysis of helical Bloch modes in N-fold rotationally symmetric rings of coupled spiraling optical waveguides