抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

We will review some of the major results in random graphs and some of the more challenging open problems. We will cover algorithmic and structural questions. We will touch on newer models, including those related to the WWW.

Random graphs

There is an increasing demand for dynamic systems to become safer and more reliable This requirement extends beyond the normally accepted safety-critical systems such as nuclear reactors and aircraft, where safety is of paramount importance, to systems such as autonomous vehicles and process control systems where the system availability is vital It is clear that fault diagnosis is becoming an important subject in modern control theory and practice Robust Model-Based Fault Diagnosis for Dynamic Systems presents the subject of model-based fault diagnosis in a unified framework It contains many important topics and methods; however, total coverage and completeness is not the primary concern The book focuses on fundamental issues such as basic definitions, residual generation methods and the importance of robustness in model-based fault diagnosis approaches In this book, fault diagnosis concepts and methods are illustrated by either simple academic examples or practical applications The first two chapters are of tutorial value and provide a starting point for newcomers to this field The rest of the book presents the state of the art in model-based fault diagnosis by discussing many important robust approaches and their applications This will certainly appeal to experts in this field Robust Model-Based Fault Diagnosis for Dynamic Systems targets both newcomers who want to get into this subject, and experts who are concerned with fundamental issues and are also looking for inspiration for future research The book is useful for both researchers in academia and professional engineers in industry because both theory and applications are discussed Although this is a research monograph, it will be an important text for postgraduate research students world-wide The largest market, however, will be academics, libraries and practicing engineers and scientists throughout the world

Robust Model-Based Fault Diagnosis for Dynamic Systems

We study a simple but compelling model of network of agents interacting via time-dependent communication links. The model finds application in a variety of fields including synchronization, swarming and distributed decision making. In the model, each agent updates his current state based upon the current information received from neighboring agents. Necessary and/or sufficient conditions for the convergence of the individual agents' states to a common value are presented, thereby extending recent results reported in the literature. The stability analysis is based upon a blend of graph-theoretic and system-theoretic tools with the notion of convexity playing a central role. The analysis is integrated within a formal framework of set-valued Lyapunov theory, which may be of independent interest. Among others, it is observed that more communication does not necessarily lead to faster convergence and may eventually even lead to a loss of convergence, even for the simple models discussed in the present paper.

Stability of multiagent systems with time-dependent communication links

The Theory of Matrices. By F R. Gantmacher. Two volumes, pp. 374 and 276. 1959. (Translated from the Russian by K. A. Hirsch; Chelsea Publishing Company, New York)

Numerical methods are described for determining robust, or well-conditioned, solutions to the problem of pole assignment by state feedback. The solutions obtained are such that the sensitivity of the assigned poles to perturbations in the system and gain matrices is minimized. It is shown that for these solutions, upper bounds on the norm of the feedback matrix and on the transient response are also minimized and a lower bound on the stability margin is maximized. A measure is derived which indicates the optimal conditioning that may be expected for a particular system with a given set of closed-loop poles, and hence the suitability of the given poles for assignment.

Robust pole assignment in linear state feedback

Considers the problems of robust stability and stabilization for uncertain continuous singular systems with state delay. The parametric uncertainty is assumed to be norm bounded. The purpose of the robust stability problem is to give conditions such that the uncertain singular system is regular, impulse free, and stable for all admissible uncertainties, while the purpose of the robust stabilization is to design a state feedback control law such that the resulting closed-loop system is robustly stable. These problems are solved via the notions of generalized quadratic stability and generalized quadratic stabilization, respectively. Necessary and sufficient conditions for generalized quadratic stability and generalized quadratic stabilization are derived. A strict linear matrix inequality (LMI) design approach is developed. An explicit expression for the desired robust state feedback control law is also given. Finally, a numerical example is provided to demonstrate the application of the proposed method.

/pdf/robust-stability-and-stabilization-for-singular-systems-with-4zvzx7fnc7.pdf

Robust stability and stabilization for singular systems with state delay and parameter uncertainty

https://perso.uclouvain.be/paul.vandooren/publications/VDooren79.pdf

The Computation of Kronecker's Canonical Form of a Singular Pencil

The algebraic theory of linear time-invariant systems has been studied in large detail during the past few decades and numerous computational algorithms have been developed to solve problems arising in this context. In this paper the numerical aspects of a certain class of such algorithms-dealing with what the author calls generalized eigenstructure problems-are discussed. Some new and/or modified algorithms are presented. Both the nmnerical stability of the algorithms and the conditioning of the problems they solve are analyzed using numerical criteria.

The generalized eigenstructure problem in linear system theory

Detecting communities in large networks has drawn much attention over the years. While modularity remains one of the more popular methods of community detection, the so-called resolution limit remains a significant drawback. To overcome this issue, it was recently suggested that instead of comparing the network to a random null model, as is done in modularity, it should be compared to a constant factor. However, it is unclear what is meant exactly by "resolution-limit-free," that is, not suffering from the resolution limit. Furthermore, the question remains what other methods could be classified as resolution-limit-free. In this paper we suggest a rigorous definition and derive some basic properties of resolution-limit-free methods. More importantly, we are able to prove exactly which class of community detection methods are resolution-limit-free. Furthermore, we analyze which methods are not resolution-limit-free, suggesting there is only a limited scope for resolution-limit-free community detection methods. Finally, we provide such a natural formulation, and show it performs superbly.

P. Van Dooren

Papers

Robust pole assignment in linear state feedback

Robust stability and stabilization for singular systems with state delay and parameter uncertainty

The Computation of Kronecker's Canonical Form of a Singular Pencil

The generalized eigenstructure problem in linear system theory

Narrow scope for resolution-limit-free community detection.