P. Villaseca

TL;DR: There is strong evidence that estrogen therapy may partly prevent this menopause-related change in body composition and the associated metabolic sequelae and further studies are required to identify the women most likely to gain metabolic benefit from menopausal hormone therapy in order to develop evidence-based clinical recommendations.

TL;DR: Regional differences in age at menopause and in climacteric symptoms are important to acknowledge and lay the foundation for an informed approach to the management of menopausal symptomatology and an understanding of its impact on women's health in the different regions of the world.

TL;DR: NAFLD is frequent in patients with PCOS confirming a relevant clinical association between these two conditions and women withPCOS should be screened for liver disease.

TL;DR: Hot flushes are caused by changes in the central nervous system associated with estrogen withdrawal and are best treated with estrogen replacement therapy, and Objective monitoring of hot flushes indicates that placebo has little to no effect on their improvement.

TL;DR: It is concluded that some interventions that can be self-initiated by healthy midlife and older adults may ameliorate cognitive aging.