Showing papers in "Journal of Hepatology in 2007"

TL;DR: Chemoembolization using DEBs is an effective procedure with a favorable pharmacokinetic profile and after a median follow-up of 27.6 months, 1- and 2-year survival is 92.5% and 88.9%, respectively.

TL;DR: Simple grading and staging systems for chronic hepatitis, including the IASL, Batts-Ludwig, and Metavir systems, are most appropriate for management of individual patients, while more complex systems such as the Histology Activity Index (HAI) are appropriate for evaluation of large cohorts of patients when statistical analysis is required.

TL;DR: Much evidence suggests that hepatitis B virus can favour the progression of liver fibrosis and above all the development of hepatocellular carcinoma, and is an entity with world-wide diffusion.

TL;DR: In this paper, the authors examined the relationship between hepatic TLR-4 expression and Kupffer cell content during the genesis of steatohepatitis in male C57BL/6 and C3H/HouJ mice.

TL;DR: NAFLD patients have a higher intake of soft drinks and meat and a tendency towards a lower intake of fish rich in omega-3 and a higher risk of NAFLD, independently of age, gender, BMI and total calories.

TL;DR: The current knowledge of the pathophysiology of liver fibrogenesis with special emphasis on MMPs and TIMPs is presented and the content is summarized in a table.

TL;DR: H-1 up-regulation by quercetin protected human hepatocytes from ethanol-induced oxidative stress and among MAPK signaling pathways, p38 and ERK mediated quercETin-derived Nrf2 translocation into nuclei and subsequent induction of HO-1 activity, and the latter showed a stronger mediating effect.

TL;DR: Transjugular liver biopsy is safe, providing specimens qualitatively comparable to PLB, and may improve further using > or = 18-G Tru-Cut needle and >3 passes, which may improve the quality of specimen and safety.

TL;DR: This paper summarizes comprehensively the current state of knowledge pertaining to the molecular mechanisms that lead to insulin resistance in hepatocytes and sinusoidal liver cells.

TL;DR: Multivariate analysis showed that IFN therapy, HBeAg seroconversion and genotype B HBV infection are independent factors for better long-term outcomes.

TL;DR: Subgroup analysis showed the majority with fibrosis belonged to the high normal ALT group and that only a minority who were young and immune tolerant had significant findings on biopsy, and increasing age, higher ALT, higher grade of inflammation on bi autopsy, and HBeAg positivity predicted fibrosis.

TL;DR: Low-density lipoprotein receptor is involved at an early stage in infection of normal human hepatocytes by serum-derived HCV virions, irrespective of genotype, viral load or liver donor.

TL;DR: unique characteristics of sinusoidal endothelial cell (SECs) and SEC dysfunctions in cirrhosis, and endothelial dysfunction in the arterial splanchnic and systemic circulation in Cirrhosis with portal hypertension are discussed.

TL;DR: Data from this unblinded, pilot study suggest that noradrenalin is as effective and safe as terlipressin in patients with HRS and these results would support the use of nor adrenalin, a cheap and widely available drug, in the management of these patients.

TL;DR: This study identified aa substitutions in the core region and serum LDL-C as predictors of response to PEG-IFN-RBV therapy in Japanese patients infected with HCV genotype 1b.

TL;DR: After a rapid training, FibroScan provides a reasonable performance for the diagnosis of cirrhosis that is not influenced substantially by any other feature.

TL;DR: Patients that later were prescribed statins had significantly higher BMI and more pronounced hepatic steatosis and despite exhibiting a high risk profile for progression of liver fibrosis, only four patients on statin treatment progressed in fibrosis stage.

TL;DR: In India, cirrhotics were prone to HEV infection, which was associated with rapid decompensation and death, and Multivariate analysis identified HEV infected patients with cirrhosis, Child-Pugh's score, renal failure, and sepsis as independent factors for mortality.

TL;DR: NAFLD was highly prevalent in potential living liver donors and the independent risk factors for significant steatosis were older age, obesity and hypertriglyceridemia.

TL;DR: Current non-invasive scores give reliable information on liver fibrosis in one-third of chronic hepatitis C patients, especially when used in combination, according to a comparison of paired-combination scores.

TL;DR: Age-standardized (world standard) cirrhosis mortality rates per 100,000 were computed for 41 countries worldwide over the period 1980-2002 using data from the WHO mortality database, showing favourable trends in most countries of the world.

TL;DR: HCC patients in HIV-positive HCC patients are younger and more frequently symptomatic and infected with HCV or HBV than HIV-negative patients, and tumor staging and survival are similar.

TL;DR: In this paper, the authors investigated the antitumoral effects of mTOR inhibition in a hepatocellular carcinoma (HCC) model and found that the mTOR inhibitor significantly reduced HCC growth and improved survival primarily via antiangiogenic effects.

TL;DR: The MnSOD mutant C allele may increase the susceptibility to DILI, and GSTM1 null genotype may be related to anti-tuberculosis drug-induced hepatotoxicity.

TL;DR: In isolated and perfused cirrhotic livers simvastatin pre-treatment significantly attenuated the pressure response to methoxamine, and significantly improved paradoxical vasoconstriction induced by acetylcholine.

TL;DR: NAFLD is frequent in patients with PCOS confirming a relevant clinical association between these two conditions and women withPCOS should be screened for liver disease.

TL;DR: In decompensated cirrhotics, HCV clearance by therapy is life-saving and reduces disease progression and early separation of SVR patients from both non-responders and controls at approximately 6 months.

TL;DR: Oral administration of resiquimod 0.02 mg/kg transiently reduced viral levels but was associated with adverse effects similar to interferon-alpha, as well as increase in neutrophil counts.

TL;DR: Responsibility rate to antiviral therapy in HCV reinfection after liver transplantation is higher if a full dose of antiviral drugs is administered and if treatment starts before histological cirrhosis has developed, which improves patient survival.