Padraig Doolan

TL;DR: Weighted gene coexpression network analysis (WGCNA) is a powerful 'guilt-by-association'-based method to extract coexpressed groups of genes from large heterogeneous messenger RNA expression data sets and a cluster of genes was found to correlate with prognosis exclusively for basal-like breast cancer.

TL;DR: This review paper provides a framework for the evaluation of clustering in gene expression analyses and surveys state of the art applications which recognise these limitations and addresses them.

TL;DR: It is concluded that miR-29a has a significant anti-invasive and anti-proliferative effect on lung cancer cells in vitro and functions as an anti-oncomir.

TL;DR: This is the first report demonstrating a functional impact of specific miRNA disregulation on CHO cell behavior in batch culture and provides some evidence of the potential which these molecules may have in terms of engineering targets in CHO production clones.

TL;DR: It is indicated that biological processes such as mRNA processing and protein synthesis are correlated with growth rate in CHO cells, and a number of proteins central to these processes were found to be post-transcriptionally regulated.