S
Sinead T Aherne
Researcher at Dublin City University
Publications - 33
Citations - 1723
Sinead T Aherne is an academic researcher from Dublin City University. The author has contributed to research in topics: microRNA & Gene expression. The author has an hindex of 17, co-authored 33 publications receiving 1556 citations. Previous affiliations of Sinead T Aherne include Moffitt Cancer Center & University College Dublin.
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Journal ArticleDOI
Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells
J Li,Paul Smyth,Richard Flavin,Susanne Cahill,K Denning,Sinead T Aherne,Simone M Guenther,John J. O'Leary,Orla Sheils +8 more
TL;DR: It is hypothesised that methylol cross-links between RNA and protein which occur during tissue processing inhibit the yield of total RNA, however, small RNA molecules appear to be less affected by this process and are recovered more easily in the extraction process.
Journal ArticleDOI
Correlating transcriptional networks to breast cancer survival: a large-scale coexpression analysis
Colin Clarke,Stephen F. Madden,Padraig Doolan,Sinead T Aherne,Helena Joyce,Lorraine O'Driscoll,William M. Gallagher,Bryan T. Hennessy,Michael Moriarty,John Crown,Susan Kennedy,Martin Clynes +11 more
TL;DR: Weighted gene coexpression network analysis (WGCNA) is a powerful 'guilt-by-association'-based method to extract coexpressed groups of genes from large heterogeneous messenger RNA expression data sets and a cluster of genes was found to correlate with prognosis exclusively for basal-like breast cancer.
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BreastMark : An Integrated Approach to Mining Publicly Available Transcriptomic Datasets Relating to Breast Cancer Outcome
Stephen F. Madden,Colin Clarke,Patricia Gaule,Sinead T Aherne,Norma O'Donovan,Martin Clynes,John Crown,William M. Gallagher +7 more
TL;DR: BreastMark is a powerful tool for examining putative gene/miRNA prognostic markers in breast cancer, and can act as a powerful reductionist approach to these more complex gene signatures, eliminating superfluous genes, potentially reducing the cost and complexity of these multi-index assays.
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A Simplified Method to Recover Urinary Vesicles for Clinical Applications, and Sample Banking
Luca Musante,Tataruch Dorota Ewa,Dongfeng Gu,Alberto Benito-Martin,Giulio Calzaferri,Sinead T Aherne,Harry Holthöfer +6 more
TL;DR: This work has developed a practical vesicle isolation technique to yield easily manageable sample volumes in an exceptionally cost efficient way to facilitate their full utilization in less privileged environments and maximize the benefit of biobanking.
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Altered eIF6 and Dicer expression is associated with clinicopathological features in ovarian serous carcinoma patients.
Richard Flavin,Paul Smyth,Stephen P. Finn,Alexandros Laios,Sharon O'Toole,Ciara Barrett,M Ring,K Denning,J Li,Sinead T Aherne,Natasha A Aziz,Araibi Alhadi,Brian L. Sheppard,Massimo Loda,Cara Martin,Orla Sheils,John J. O'Leary +16 more
TL;DR: In this article, the ribosome anti-association factor eIF6 has been found to have a role in microRNA-mediated post-transcriptional silencing.