Pal Gooz

TL;DR: It is demonstrated that systemic administration of CSD peptide to bleomycin-treated mice blocks epithelial cell apoptosis, inflammatory cell infiltration, and changes in tissue morphology as well as signaling molecule activation and collagen, tenascin-C, and ASMA expression associated with lung fibrosis.

TL;DR: The combined results demonstrate that a branched signaling pathway involving MEK, ERK, PKCϵ,PKCα, and caveolin-1 regulates collagen expression in normal lung tissue and is perturbed during fibrosis.

TL;DR: It is suggested that a signaling pathway involving PKCepsilon and phase 2 detoxification enzymes provides protection against curcumin-induced apoptosis in NLF and is defective in SLF, just as it has already been shown to protect rats from lung fibrosis induced by a variety of agents.

TL;DR: The data indicate that MMP and TIMP secretion by AGS cells is modulated by H. pylori infection and that host MMP-3 and a TIMP-3 homolog expressed by the bacterium mediate at least part of the host cell response to infection.

TL;DR: Caveolin-1 downregulation in leucocytes contributes to fibrotic lung disease, highlighting caveolin- 1 as a promising therapeutic target in scleroderma.