P
Pål Ø. Falnes
Researcher at University of Oslo
Publications - 73
Citations - 5142
Pål Ø. Falnes is an academic researcher from University of Oslo. The author has contributed to research in topics: Methylation & AlkB. The author has an hindex of 34, co-authored 69 publications receiving 4608 citations. Previous affiliations of Pål Ø. Falnes include Oslo University Hospital & Norwegian University of Science and Technology.
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Journal ArticleDOI
Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA
Per Arne Aas,Marit Otterlei,Pål Ø. Falnes,Cathrine Broberg Vågbø,Frank Skorpen,Mansour Akbari,Ottar Sundheim,Magnar Bjørås,Geir Slupphaug,Erling Seeberg,Hans E. Krokan +10 more
TL;DR: The different catalytic properties and the different subnuclear localization patterns shown by the human homologues indicate that hABH2 and hABh3 have distinct roles in the cellular response to alkylation damage, which is important for establishing RNA repair as a potentially important defence mechanism in living cells.
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AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli
TL;DR: It is shown that AlkB from Escherichia coli is indeed a 2-oxoglutarate-dependent and iron-dependent DNA repair enzyme that releases replication blocks in alkylated DNA by a mechanism involving oxidative demethylation of 1-methyladenine residues.
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Penetration of protein toxins into cells
Pål Ø. Falnes,Kirsten Sandvig +1 more
TL;DR: Some AB-toxins depend on retrograde transport through the secretory pathway to the ER before translocation, and recent findings suggest that these toxins take advantage of the ER translocation machinery normally used for transport of cellular proteins.
Journal ArticleDOI
Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol
TL;DR: The finding that glycosylated A chain was present in the cytosol indicates that translocation takes place after transport of the toxin to the ER.
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Dual Mode of Signal Transduction by Externally Added Acidic Fibroblast Growth Factor
TL;DR: Results indicate that signaling occurs partly through cell surface receptors and partly by transport of the growth factor into the cell as well as stimulated DNA synthesis in toxin-resistant cells lacking functional aFGF receptors while having a high number of diphtheria toxin receptors.