K
Kirsten Sandvig
Researcher at Oslo University Hospital
Publications - 295
Citations - 22702
Kirsten Sandvig is an academic researcher from Oslo University Hospital. The author has contributed to research in topics: Endocytosis & Ricin. The author has an hindex of 79, co-authored 288 publications receiving 20756 citations. Previous affiliations of Kirsten Sandvig include University of Copenhagen & University of Oslo.
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Journal ArticleDOI
Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
TL;DR: The use of pharmacological inhibitors, expression of mutated proteins, use of siRNAs and colocalization experiments in such studies are critically evaluated and aspects of intracellular transport, recycling of nanoparticle to the cell exterior, disturbance of cellular functions, and metabolism of nanoparticles are discussed.
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Extraction of Cholesterol with Methyl-β-Cyclodextrin Perturbs Formation of Clathrin-coated Endocytic Vesicles
Siv Kjersti Rodal,Grethe Skretting,Øystein Garred,Frederik Vilhardt,Bo van Deurs,Kirsten Sandvig +5 more
TL;DR: The results indicate that although clathrin-independent (and caveolae-independent) endocytosis still operates after removal of cholesterol, cholesterol is essential for the formation of clathin-coated endocytic vesicles.
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Lipids in exosomes: Current knowledge and the way forward.
TL;DR: Current knowledge about the lipid composition of exosomes is discussed, and the hypothesis about hand-shaking between the very-long-chain sphingolipids in the outer leaflet and PS 18:0/18:1 in the inner leaflet is elaborate.
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Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.
Alicia Llorente,Tore Skotland,Tore Skotland,Tuulia Sylvänne,Dimple Kauhanen,Tomasz Róg,Adam Orłowski,Ilpo Vattulainen,Ilpo Vattulainen,Kim Ekroos,Kirsten Sandvig,Kirsten Sandvig +11 more
TL;DR: The detailed lipid composition provided in this study may be useful to understand the mechanism of exosome formation, release and function, and several of the lipids enriched in exosomes could potentially be used as cancer biomarkers.
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Retrograde transport of endocytosed Shiga toxin to the endoplasmic reticulum
TL;DR: It is shown that in butyric acid-treated A431 cells endocytosed Shiga toxin is not only transported to the trans-Golgi network, but also to all Golgi stacks, to the endoplasmic reticulum and to the nuclear envelope.