P
Palani Gunasekaran
Researcher at King Institute of Preventive Medicine and Research
Publications - 47
Citations - 2258
Palani Gunasekaran is an academic researcher from King Institute of Preventive Medicine and Research. The author has contributed to research in topics: Virus & Apoptosis. The author has an hindex of 23, co-authored 46 publications receiving 1882 citations.
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Journal ArticleDOI
Green biosynthesis of silver nanoparticles from Annona squamosa leaf extract and its in vitro cytotoxic effect on MCF-7 cells
Raju Vivek,Ramar Thangam,Ramar Thangam,K. Muthuchelian,Palani Gunasekaran,Krishnasamy Kaveri,Soundarapandian Kannan +6 more
TL;DR: In this article, a biological method for the synthesis of silver nanoparticles (AgNPs) using Annona squamosa leaf extract and its cytotoxicity against MCF-7 cells are reported.
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Cytotoxic effect of Green synthesized silver nanoparticles using Melia azedarach against in vitro HeLa cell lines and lymphoma mice model
Raman Sukirtha,Kandula Manasa Priyanka,Jacob Joe Antony,Soundararajan Kamalakkannan,Ramar Thangam,Palani Gunasekaran,Muthukalingan Krishnan,Shanmugam Achiraman +7 more
TL;DR: In vivo DAL mice model showed significant increase in life span, induction of apoptosis was evidenced by acridine orange and ethidium bromide staining, and Cytotoxicity of biosynthesized AgNPs against in vitro Human epithelial carcinoma cell line (HeLa) showed a dose–response activity.
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Correction: Corrigendum: Combinatorial nanocarrier based drug delivery approach for amalgamation of anti-tumor agents in breast cancer cells: an improved nanomedicine strategy
Chandran Murugan,Kathirvel Rayappan,Ramar Thangam,Ramasamy Bhanumathi,Krishnamurthy Shanthi,Raju Vivek,Ramasamy Thirumurugan,Atanu Bhattacharyya,Srinivasan Sivasubramanian,Palani Gunasekaran,Soundarapandian Kannan +10 more
TL;DR: This research presents a novel probabilistic procedure called “spot-spot analysis” that allows for direct measurement of the response of the immune system to chemotherapy-like substances.
Journal ArticleDOI
γ-Sitosterol from Acacia nilotica L. induces G2/M cell cycle arrest and apoptosis through c-Myc suppression in MCF-7 and A549 cells.
Shenbagamoorthy Sundarraj,Ramar Thangam,Ramar Thangam,Vellingiri Sreevani,Krishnasamy Kaveri,Palani Gunasekaran,Shanmugam Achiraman,Soundarapandian Kannan +7 more
TL;DR: Flow cytometric analysis results demonstrate that cells were arrested at the G2/M phase and decrease the c-Myc expression, which support the ethnomedical use of γ-Sitosterol against cancer.
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Multifunctional HER2-Antibody Conjugated Polymeric Nanocarrier-Based Drug Delivery System for Multi-Drug-Resistant Breast Cancer Therapy
Raju Vivek,Ramar Thangam,Ramar Thangam,Varukattu NipunBabu,Chandrababu Rejeeth,Srinivasan Sivasubramanian,Palani Gunasekaran,K. Muthuchelian,Soundarapandian Kannan,Soundarapandian Kannan +9 more
TL;DR: This nanocarrier drug delivery system (DDS) not only actively targets a multidrug-resistance (MDR) associated phenotype (HER2 receptor overexpression) but also improves therapeutic efficiency by enhancing the cancer cell targeted delivery and sustained release of therapeutic agents.