P
Paloma Perez
Researcher at Research Triangle Park
Publications - 2
Citations - 404
Paloma Perez is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Acetylation & Fusion protein. The author has an hindex of 2, co-authored 2 publications receiving 383 citations.
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Journal ArticleDOI
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
Erding Hu,Edward Dul,Chiu-Mei Sung,Zunxuan Chen,Robert B. Kirkpatrick,Gui-Feng Zhang,Kyung O. Johanson,Ronggang Liu,Lago Amparo M,Glenn A. Hofmann,Ricardo Macarron,Maite de los Frailes,Paloma Perez,Krawiec John A,James D. Winkler,Michael Jaye +15 more
TL;DR: Using purified recombinant HDAC proteins, several novel HDAC inhibitors that preferentially inhibit HDAC1 or HDAC8 are identified and displayed distinct properties in inducing histone acetylation and reporter gene expression.
Journal ArticleDOI
Discovery of Substituted Maleimides as Liver X Receptor Agonists and Determination of a Ligand-Bound Crystal Structure
Michael Jaye,John A. Krawiec,Nino Campobasso,Angela Smallwood,Chunyan Qiu,Quinn Lu,John J. Kerrigan,Maite De Los Frailes Alvaro,Bryan A. Laffitte,Wu Schyong Liu,Joseph P. Marino,Craig R. Meyer,Jason Nichols,Derek J. Parks,Paloma Perez,Lea Sarov-Blat,Sheila Seepersaud,Klaudia Steplewski,Scott K. Thompson,Ping Wang,Michael A. Watson,Christine L. Webb,David Haigh,Justin A. Caravella,Colin H. Macphee,Timothy M. Willson,Jon L. Collins +26 more
TL;DR: Substituted 3-(phenylamino)-1H-pyrrole-2,5-diones were identified from a high throughput screen as inducers of human ATP binding cassette transporter A1 expression and GSK3987 was identified as an LXR ligand.