Z
Zunxuan Chen
Researcher at GlaxoSmithKline
Publications - 7
Citations - 963
Zunxuan Chen is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Gene & Profilin. The author has an hindex of 6, co-authored 7 publications receiving 913 citations.
Papers
More filters
Journal ArticleDOI
Identification of Novel Isoform-Selective Inhibitors within Class I Histone Deacetylases
Erding Hu,Edward Dul,Chiu-Mei Sung,Zunxuan Chen,Robert B. Kirkpatrick,Gui-Feng Zhang,Kyung O. Johanson,Ronggang Liu,Lago Amparo M,Glenn A. Hofmann,Ricardo Macarron,Maite de los Frailes,Paloma Perez,Krawiec John A,James D. Winkler,Michael Jaye +15 more
TL;DR: Using purified recombinant HDAC proteins, several novel HDAC inhibitors that preferentially inhibit HDAC1 or HDAC8 are identified and displayed distinct properties in inducing histone acetylation and reporter gene expression.
Journal ArticleDOI
Cloning and Characterization of a Novel Human Class I Histone Deacetylase That Functions as a Transcription Repressor
Erding Hu,Zunxuan Chen,Todd Fredrickson,Yuan Zhu,Robert B. Kirkpatrick,Gui-Feng Zhang,Kyung O. Johanson,Chiu-Mei Sung,Ronggang Liu,James D. Winkler +9 more
TL;DR: Results indicate that HDAC8 is a novel member of the histone deacetylase family, which may play a role in the development of a broad range of tissues and potentially in the etiology of cancer.
Journal ArticleDOI
Novel Rho Kinase Inhibitors with Anti-inflammatory and Vasodilatory Activities
Chris P. Doe,Ross G. Bentley,David J. Behm,Robert Lafferty,Robert A. Stavenger,David Kendall Jung,Mark James Bamford,Terry Panchal,Eugene T. Grygielko,Lois L. Wright,Gary K. Smith,Zunxuan Chen,Christine Webb,Sanjay S. Khandekar,Tracey Yi,Robert B. Kirkpatrick,Edward Dul,Larry J. Jolivette,Joseph P. Marino,Robert N. Willette,Dennis Lee,Erding Hu +21 more
TL;DR: Two aminofurazan-based ROCK inhibitors are characterized, GSK269962A and SB-772077-B, as members of a novel class of compounds that potently inhibit ROCK enzymatic activity and may enable us to further evaluate the potential beneficial effects of ROCK inhibition in animal models of cardiovascular as well as other chronic diseases.
Journal ArticleDOI
Induction and superinduction of growth arrest and DNA damage gene 45 (GADD45) α and β messenger RNAs by histone deacetylase inhibitors trichostatin A (TSA) and butyrate in SW620 human colon carcinoma cells
Zunxuan Chen,Steven Clark,Marian L Birkeland,Chiu Mei Sung,Lago Amparo M,Ronggang Liu,Robert B. Kirkpatrick,Kyung O. Johanson,James D. Winkler,Erding Hu +9 more
TL;DR: It is shown that in the SW620 human colon cancer cell line, TSA and butyrate induced the growth arrest and DNA damage gene 45alpha (GADD45alpha) and GADD45beta, indicating that both genes were immediate target genes for TSA.
Journal ArticleDOI
Molecular cloning and characterization of profilin-3: a novel cytoskeleton-associated gene expressed in rat kidney and testes.
TL;DR: The results strongly suggest that, contrary to the ubiquitous presence of profilin-1 and profILin-2, there is a tissue-specific form of these cytoskeleton-regulatory proteins and that the kidney/testes-specific profilIn-3 may play a unique role in renal and/or reproductive functions.