Pamela E. Constantinou

TL;DR: The data demonstrate clearly that it is possible to design and self-assemble a well-ordered macromolecular 3D crystalline lattice with precise control.

TL;DR: In this article, robust three-space-spanning DNA motifs are used to organize nanoparticles in two dimensions, using two of the directions of the motif to produce a two-dimensional crystalline array, one direction is free to bind gold nanoparticles.

TL;DR: The results imply that cargos will tend to be carried by only a fraction of the total number of kinesins that are available for transport at any given time, and provide an alternative explanation for observations that intracellular transport depends weakly on kinesin number in vivo.

TL;DR: A biosynthetic method is presented that enables exactly two kinesin-1 molecules to be organized on linear scaffolds that separate the motors by a distance of 50 nm and it is proposed that negative motor interference derived from asynchronous motor stepping and the communication of forces between motors leads to this behavior by promoting the rapid exchange between different microtubule-bound configurations of the assemblies.

TL;DR: It is confirmed that 3D triangles form well only when their geometrical strain is less than 4% deviation from the estimated relaxed structure, so geometry-based techniques alone, without detailed energetic considerations, can be used to explain certain general trends in DNA structure formation.