Pamela McKenzie

TL;DR: It is demonstrated that nuclear p53 protein is expressed in a panel of neuroblastoma cell lines, and after exposure to DNA damage, transcriptionally active p53 expression can be induced and the ability of p53 to induce apoptosis appears functional, consistent with its chemosensitive phenotype.

TL;DR: Genetic and antigenic analyses of viruses revealed that influenza A(H5N1) clade 2.2.1 viruses are dominant and that all subtype H9N2 viruses are G1-like, which poses concern for potential reassortment.

TL;DR: Molecular analysis showed that multiple mammalian-specific mutations have become fixed in the subtype H9N2 viruses, including changes in the hemagglutinin, matrix, and polymerase proteins, indicating that these viruses could mutate to be transmissible from birds to mammals, including humans.

TL;DR: The number of humans infected with avian influenza viruses is much larger than the number of reported confirmed cases, and in an area where these viruses are enzootic in the poultry, human exposure to and infection withAvian influenza becomes more common.

TL;DR: An aggressive plan to curb these infections in poultry is urgently needed.