John Franks

TL;DR: Reduction rather than total elimination of tipDC trafficking is shown by treatment with the peroxisome proliferator-activated receptor-γ agonist pioglitazone, which moderates the potentially lethal consequences of excessive tipDC recruitment without abrogating CD8+ T cell expansion or compromising virus control.

TL;DR: In this paper , the authors evaluated the ability of several B.1.529 isolates to cause infection and disease in immunocompetent and human ACE2 (hACE2)-expressing mice and hamsters.

TL;DR: It is suggested that for high virulence in mammalian species an avian H5N1 virus with a cleavable hemagglutinin requires adaptive changes in polymerase genes to overcome the species barrier, and novel antivirals targeting polymerase proteins should be developed.

TL;DR: Overall, the available evidence does not support the perpetuation of HP H5N1 influenza in migratory birds and suggests that the introduction of HP Asian H 5N1 to the Americas by migratoryirds is likely to be a rare event.

TL;DR: Results show that the PA and PB1 genes of HP H5N1 influenza viruses are associated with lethality in ducks, and the mechanisms of lethality and the perpetuation of this lethal phenotype in ducks in nature remain to be determined.