P
Pankaj Chopra
Researcher at University of Maryland, Baltimore
Publications - 7
Citations - 603
Pankaj Chopra is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Acute promyelocytic leukemia & Liarozole. The author has an hindex of 7, co-authored 7 publications receiving 574 citations. Previous affiliations of Pankaj Chopra include University of Maryland Marlene and Stewart Greenebaum Cancer Center.
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Journal ArticleDOI
Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model
Venkatesh D. Handratta,Tadas S. Vasaitis,Vincent C. O. Njar,Lalji K. Gediya,Ritesh Kataria,Pankaj Chopra,Donnell Newman,Rena Farquhar,Zhiyong Guo,Yun Qiu,Angela Brodie +10 more
TL;DR: To the authors' knowledge, this is the first example of an antihormonal agent (an inhibitor of androgen synthesis (CYP17 inhibitor)/antiandrogen) that is significantly more effective than castration in suppression of androgens-dependent prostate tumor growth.
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Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.
Vincent C. O. Njar,Lalji K. Gediya,Lalji K. Gediya,Puranik Purushottamachar,Puranik Purushottamachar,Pankaj Chopra,Pankaj Chopra,Tadas S. Vasaitis,Tadas S. Vasaitis,Aakanksha Khandelwal,Aakanksha Khandelwal,Jhalak Mehta,Jhalak Mehta,Carlic Huynh,Carlic Huynh,Aashvini Belosay,Aashvini Belosay,Jyoti Patel,Jyoti Patel +18 more
TL;DR: A novel strategy to overcome the limitation associated with exogenous ATRA therapy has been to modulate and/or increase the levels of endogenous ATRA by inhibiting the cytochrome P450-dependent ATRA-4-hydroxylase enzymes (particularly CYP26s) responsible for ATRA metabolism.
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A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.
TL;DR: SAHA is a potent inhibitor of histone deacetylase, induces differentiation and/or apoptosis in certain transformed cells in culture, and suppressed the growth of human prostate cancer LNCaP and PC-3 cell lines.
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First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.
Puranik Purushottamachar,Aakanksha Khandelwal,Pankaj Chopra,Neha Maheshwari,Lalji K. Gediya,Tadas S. Vasaitis,Robert D. Bruno,Omoshile O. Clement,Vincent C. O. Njar,Vincent C. O. Njar +9 more
TL;DR: A qualitative 3D pharmacophore model was developed for well-known natural product androgen receptor down-regulating agents (ARDAs) and served as a template in virtual screening of the Maybridge and NCI databases that resulted in identification of six new ARDAs.
Journal ArticleDOI
Retinoic Acid Metabolism Blocking Agents (RAMBAs) for Treatment of Cancer and Dermatological Diseases
Vincent C. O. Njar,Lalji K. Gediya,Lalji K. Gediya,Puranik Purushottamachar,Puranik Purushottamachar,Pankaj Chopra,Pankaj Chopra,Tadas S. Vasaitis,Tadas S. Vasaitis,Aakanksha Khandelwal,Aakanksha Khandelwal,Jhalak Mehta,Jhalak Mehta,Carlic Huynh,Carlic Huynh,Aashvini Belosay,Aashvini Belosay,Jyoti Patel,Jyoti Patel +18 more
TL;DR: A review on the role of all-trans-retinoic acid (ATRA), the principal endogenous metabolite of vitamin A (retinol), and its metabolism in oncology and dermatology is presented in this paper.