Robert D. Bruno

TL;DR: This review offers the first comprehensive analysis of strategies in drug development that either inhibit or exploit CYP enzymes for the treatment of cancer.

TL;DR: The role of androgen biosynthesis in the progression of prostate cancer and the impact of CYP17 inhibitors, such as ketoconazole, abiraterone acetate, VN/124-1 (TOK-001) and TAK-700 in the clinic and in clinical development are highlighted.

TL;DR: A novel mammary-specific culture protocol that combines a self-gelling hydrogel comprised solely of ECM from decellularized rat or human breast tissue with the use of the previously described 3D bioprinting platform is described, providing a suitable platform for ECM and epithelial/cancer cell studies.

TL;DR: The results show that human embryonal carcinoma-derived progeny interact with mouse mammary cells during mammary gland regeneration and are directed to differentiate into cells that exhibit diverse mammary epithelial cell phenotypes.

TL;DR: This work designed and 3D printed components for the adaptation of an inexpensive 'off-the-shelf' commercially available 3D printer to circumvent the high-price barrier to entry of conventional bioprinters and demonstrates an accessible open-source 3D bioprinter capable of serving the needs of any laboratory interested in 3D cellular interactions and tissue engineering.