Panpan Hao

TL;DR: Results indicate that TCM might be used as a complementary and alternative approach to the primary and secondary prevention of cardiovascular disease, however, further rigorously designed randomized controlled trials are warranted to assess the effect of TCM on long-term hard endpoints in patients with cardiovascular disease.

TL;DR: Diabetic rats exhibited significant reduction in LV ejection fraction and fractional shortening, accompanied by decreases in ALDH2 activity and expression, which might reflect an underlying mechanism which causes cardiac dysfunction in diabetic rats.

TL;DR: Whether TCM is effective in reducing the all-cause or cardiovascular mortality in patients with CVD remains unknown and must be tested in large-scale RCTs with adverse cardiovascular events as primary end points.

TL;DR: ALDH2 may protect hearts against I/R injury by suppressing PINK1/Parkin–dependent mitophagy by preventing 4-hydroxynonenal, reactive oxygen species and mitochondrial superoxide accumulation.

TL;DR: It is shown that in human aortic endothelial cells (HAECs), rapid activation of mitochondrial aldehyde dehydrogenase 2 (ALDH2) mediates ethanol‐induced eNOS activation by preventing reactive oxygen species (ROS) accumulation.