Pao-Yen Lin

TL;DR: Although the meta-analysis showed significant antidepressant efficacy of omega-3 PUFAs, it is still premature to validate this finding due to publication bias and heterogeneity.

TL;DR: These findings provide further support to the phospholipid hypothesis of depression and a rationale for using n-3 polyunsaturated fatty acids as an alternative treatment for depression, and future studies examining specific roles of DHA and EPA in different clusters of depressive symptoms are warranted.

TL;DR: A meta-analysis of all the double-blind, placebo-controlled studies in patients with schizophrenia was performed to examine their efficacy on different symptom domains, the dose-response, the effects of concomitant antipsychotics, and their side effects, revealing that glycine, D-serine and sarcosine are better than D-cycloserine in improving the overall psychopathology.

TL;DR: The results provide significant evidence supporting the association of the s allele of 5-HTTLPR polymorphism with suicidal behavior in the psychiatric population, also with violent suicide, and support a role for decreased serotonin transporter function in the vulnerability to suicide in a select population.

TL;DR: Sarcosine was well tolerated and no significant side-effect was noted, and unlike patients treated with other antipsychotics, patients who received clozapine treatment exhibit no improvement by adding sarcosine or agonists at the NMDA-glycine site.