P
Paola De Cesaris
Researcher at University of L'Aquila
Publications - 33
Citations - 1669
Paola De Cesaris is an academic researcher from University of L'Aquila. The author has contributed to research in topics: Sertoli cell & Apoptosis. The author has an hindex of 21, co-authored 31 publications receiving 1527 citations. Previous affiliations of Paola De Cesaris include Sapienza University of Rome.
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Toll-like receptor 3 triggers apoptosis of human prostate cancer cells through a PKC-α-dependent mechanism
Alessio Paone,Donatella Starace,Roberta Galli,Fabrizio Padula,Paola De Cesaris,Antonio Filippini,Elio Ziparo,Anna Riccioli +7 more
TL;DR: It is shown that a novel interferon-independent pathway involving protein kinase C (PKC)-alpha activation, upstream of p38 and c-jun N-terminal kinase, is responsible for poly (I:C) pro-apoptotic effects on LNCaP cells.
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Testicular FasL is expressed by sperm cells
Alessio D'Alessio,Anna Riccioli,P Lauretti,Fabrizio Padula,Barbara Muciaccia,Paola De Cesaris,Antonio Filippini,Shigekazu Nagata,Elio Ziparo +8 more
TL;DR: It is demonstrated that the attribution of testicular expression of FasL to Sertoli cells is erroneous and that FasL transcription instead occurs in meiotic and postmeiotic germ cells, whereas the protein is only displayed on mature spermatozoa.
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Sertoli Cells Initiate Testicular Innate Immune Responses through TLR Activation
Anna Riccioli,Donatella Starace,Roberta Galli,Andrea Fuso,Sigfrido Scarpa,Fioretta Palombi,Paola De Cesaris,Elio Ziparo,Antonio Filippini +8 more
TL;DR: The novel ability of Sertoli cells to potentially respond to a wide variety of bacteria through TLR stimulation is demonstrated and the role of NF-κB and of MAPKs in regulating TLR-mediated MCP-1 secretion is studied.
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PKCα-mediated ERK, JNK and p38 activation regulates the myogenic program in human rhabdomyosarcoma cells
Annunziata Mauro,Carmela Ciccarelli,Paola De Cesaris,Arianna Scoglio,Marina Bouché,Mario Molinaro,Angelo Aquino,Bianca M. Zani +7 more
TL;DR: Notably, sarcomeric myosin expression is induced by both TPA and UO126 but is abrogated by the p38 inhibitor, which indicates a pivotal role for p38 in controlling the myogenic program.
Journal ArticleDOI
Tumor Necrosis Factor-α Induces Interleukin-6 Production and Integrin Ligand Expression by Distinct Transduction Pathways
Paola De Cesaris,Paola De Cesaris,Donatella Starace,Anna Riccioli,Fabrizio Padula,Antonio Filippini,Elio Ziparo +6 more
TL;DR: The data strongly support the hypothesis that, in response to TNF-α, activation of p38 leads to IL-6 production, whereas ICAM-1 and VCAM- 1 expression could be induced by activation of the c-Jun N-terminal protein kinase/stress-activatedprotein kinase pathway.