M
Mario Molinaro
Researcher at Sapienza University of Rome
Publications - 116
Citations - 6136
Mario Molinaro is an academic researcher from Sapienza University of Rome. The author has contributed to research in topics: Myogenesis & Myocyte. The author has an hindex of 39, co-authored 111 publications receiving 5923 citations. Previous affiliations of Mario Molinaro include University of L'Aquila & University of Naples Federico II.
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Journal ArticleDOI
Localized Igf-1 transgene expression sustains hypertrophy and regeneration in senescent skeletal muscle
Antonio Musarò,Karl J. A. McCullagh,Angelika Christina Paul,Leslie Houghton,Gabriella Dobrowolny,Mario Molinaro,Elisabeth R. Barton,H. L. Sweeney,Nadia Rosenthal +8 more
TL;DR: A model of persistent, functional myocyte hypertrophy is generated using a tissue-restricted transgene encoding a locally acting isoform of insulin-like growth factor-1 that is expressed in skeletal muscle (mIgf-1) and suggests clinical strategies for the treatment of age or disease-related muscle frailty.
Journal ArticleDOI
Skeletal muscle is a primary target of SOD1G93A-mediated toxicity.
Gabriella Dobrowolny,Michela Aucello,Emanuele Rizzuto,Sara Beccafico,Cristina Mammucari,Simona Bonconpagni,Silvia Belia,Francesca Wannenes,Carmine Nicoletti,Zaccaria Del Prete,Nadia Rosenthal,Mario Molinaro,Feliciano Protasi,Giorgio Fanò,Marco Sandri,Antonio Musarò,Antonio Musarò +16 more
TL;DR: It is demonstrated that skeletal muscle is a primary target of SOD1(G93A) -mediated toxicity and the molecular mechanism whereby oxidative stress triggers muscle atrophy is disclosed.
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Muscle expression of a local Igf-1 isoform protects motor neurons in an ALS mouse model
Gabriella Dobrowolny,Cristina Giacinti,Laura Pelosi,Carmine Nicoletti,Nadine Winn,Laura Barberi,Mario Molinaro,Nadia Rosenthal,Antonio Musarò,Antonio Musarò +9 more
TL;DR: In this article, muscle-restricted expression of localized insulin-like growth factor (Igf) -1 isoform maintained muscle integrity and enhanced satellite cell activity in SOD1G93A transgenic mice, inducing calcineurin-mediated regenerative pathways.
Journal ArticleDOI
Cellular heterogeneity during vertebrate skeletal muscle development.
TL;DR: A comprehensive view of relevant findings in skeletal muscle formation and heterogeneity is presented, showing multiple waves of muscle precursors with different features appear before birth and contribute to muscular diversity.
Journal ArticleDOI
Local expression of IGF-1 accelerates muscle regeneration by rapidly modulating inflammatory cytokines and chemokines
Laura Pelosi,Cristina Giacinti,C. Nardis,Giovanna Borsellino,Emanuele Rizzuto,Carmnine Nicoletti,Francesca Wannenes,Luca Battistini,Nadia Rosenthal,Mario Molinaro,Antonio Musarò +10 more
TL;DR: It is shown that local expression of a muscle‐restricted insulin‐like growth factor (IGF)‐1 (mIGF‐1) transgene accelerates the regenerative process of injured skeletal muscle, modulating the inflammatory response, and limiting fibrosis.