P
Paolo Mascagni
Researcher at University of London
Publications - 121
Citations - 5335
Paolo Mascagni is an academic researcher from University of London. The author has contributed to research in topics: Proinflammatory cytokine & Histone deacetylase inhibitor. The author has an hindex of 35, co-authored 120 publications receiving 5024 citations. Previous affiliations of Paolo Mascagni include University of Colorado Denver & St George's Hospital.
Papers
More filters
Journal ArticleDOI
The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Flavio Leoni,Andrea Zaliani,Giorgio Bertolini,Giulia Porro,Paolo Pagani,Pietro Pozzi,Giancarlo Dona,Gianluca Fossati,Silvano Sozzani,Silvano Sozzani,Tania Azam,Philip Bufler,Giamila Fantuzzi,Igor Goncharov,Soo-Hyun Kim,Pomerantz Benjamin,Leonid L. Reznikov,Britta Siegmund,Charles A. Dinarello,Paolo Mascagni +19 more
TL;DR: It is found that SAHA reduces the production of proinflammatory cytokines in vivo and in vitro and may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets.
Journal ArticleDOI
The Histone Deacetylase Inhibitor ITF2357 Reduces Production of Pro-Inflammatory Cytokines In Vitro and Systemic Inflammation In Vivo
Flavio Leoni,Gianluca Fossati,Eli C. Lewis,Jae-Kwon Lee,Giulia Porro,Paolo Pagani,Daniela Modena,Maria Lusia Moras,Pietro Pozzi,Leonid L. Reznikov,Britta Siegmund,Giamila Fantuzzi,Charles A. Dinarello,Paolo Mascagni +13 more
TL;DR: Low, nonapoptotic concentrations of the HDAC inhibitor ITF2357 reduce pro-inflammatory cytokine production in primary cells in vitro and exhibit anti-inflammatory effects in vivo.
Journal ArticleDOI
Histone Hyperacetylation Is Associated with Amelioration of Experimental Colitis in Mice
Rainer Glauben,Arvind Batra,I. Fedke,Martin Zeitz,Hans A. Lehr,Flavio Leoni,Paolo Mascagni,Giamila Fantuzzi,Charles A. Dinarello,Britta Siegmund,Britta Siegmund +10 more
TL;DR: Inhibitors of HDAC reveal strong protective effects in different models of experimental colitis by inducing apoptosis and suppressing proinflammatory cytokines, thereby representing a promising class of compounds for clinical studies in human inflammatory bowel disease.
Journal ArticleDOI
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice
Pavan Reddy,Yaping Sun,Tomomi Toubai,Raimon Duran-Struuck,Shawn G. Clouthier,Elizabeth Weisiger,Yoshinobu Maeda,Isao Tawara,Oleg I. Krijanovski,Erin Gatza,Chen Liu,Chelsea Malter,Paolo Mascagni,Charles A. Dinarello,James L.M. Ferrara +14 more
TL;DR: Data show that HDAC inhibitors regulate multiple DC functions through the induction of IDO and suggest that they may represent a novel class of agents to treat immune-mediated diseases.
Journal ArticleDOI
Pharmacological inhibition of histone deacetylases by suberoylanilide hydroxamic acid specifically alters gene expression and reduces ischemic injury in the mouse brain.
Giuseppe Faraco,Tristano Pancani,Laura Formentini,Paolo Mascagni,Gianluca Fossati,Flavio Leoni,Flavio Moroni,Alberto Chiarugi +7 more
TL;DR: It is demonstrated that pharmacological inhibition ofHDACs promotes expression of neuroprotective proteins within the ischemic brain and underscores the therapeutic potential of molecules inhibiting HDACs for stroke therapy.