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Isao Tawara
Researcher at University of Michigan
Publications - 24
Citations - 1742
Isao Tawara is an academic researcher from University of Michigan. The author has contributed to research in topics: Graft-versus-host disease & Antigen-presenting cell. The author has an hindex of 19, co-authored 24 publications receiving 1671 citations.
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Journal ArticleDOI
Histone deacetylase inhibition modulates indoleamine 2,3-dioxygenase–dependent DC functions and regulates experimental graft-versus-host disease in mice
Pavan Reddy,Yaping Sun,Tomomi Toubai,Raimon Duran-Struuck,Shawn G. Clouthier,Elizabeth Weisiger,Yoshinobu Maeda,Isao Tawara,Oleg I. Krijanovski,Erin Gatza,Chen Liu,Chelsea Malter,Paolo Mascagni,Charles A. Dinarello,James L.M. Ferrara +14 more
TL;DR: Data show that HDAC inhibitors regulate multiple DC functions through the induction of IDO and suggest that they may represent a novel class of agents to treat immune-mediated diseases.
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Extracorporeal photopheresis reverses experimental graft-versus-host disease through regulatory T cells.
Erin Gatza,Clare E. Rogers,Shawn G. Clouthier,Kathleen P. Lowler,Isao Tawara,Chen Liu,Pavan Reddy,James L.M. Ferrara +7 more
TL;DR: It is demonstrated that the transfer of cells treated with ECP reverses established GVHD by increasing donor regulatory T cells and indirectly reducing the number of donor effector lymphocytes that themselves had never been exposed to psoralen and ultraviolet A radiation.
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Interleukin-6 Modulates Graft-versus-Host Responses after Experimental Allogeneic Bone Marrow Transplantation
Isao Tawara,Motoko Koyama,Chen Liu,Tomomi Toubai,Dafydd G. Thomas,Rebecca Evers,Peter Chockley,Evelyn Nieves,Yaping Sun,Kathleen P. Lowler,Chelsea Malter,Norihiro Nishimoto,Geoffrey R. Hill,Pavan Reddy +13 more
TL;DR: Blockade of IL-6 with anti–IL-6R mAb therapy may be testable in clinical trials as an adjunct to prevent GVHD in BMT patients without a significant loss of GVT.
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Targeting of microRNA-142-3p in dendritic cells regulates endotoxin-induced mortality
Yaping Sun,Sooryanarayana Varambally,Christopher G. Maher,Qi Cao,Peter Chockley,Tomomi Toubai,Chelsea Malter,Evelyn Nieves,Isao Tawara,Yongqing Wang,Peter A. Ward,Arul M. Chinnaiyan,Pavan Reddy +12 more
TL;DR: A critical role for miR-142-3p in regulating DC responses to LPS is demonstrated and proof of concept for targeting miRs as a novel strategy for treatment of endotoxin-induced mortality is provided.
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Frequency of CD4+CD25hiFOXP3+ Regulatory T Cells Has Diagnostic and Prognostic Value as a Biomarker for Acute Graft-versus-Host-Disease
John M. Magenau,Xuemei Qin,Xuemei Qin,Isao Tawara,Clare E. Rogers,Carrie L. Kitko,Matthew Schlough,Daniel Bickley,Thomas Braun,Pil Sang Jang,Pil Sang Jang,Kathleen P. Lowler,Dawn Jones,Sung Won Choi,Pavan Reddy,Shin Mineishi,John E. Levine,James L.M. Ferrara,Sophie Paczesny +18 more
TL;DR: Treg frequency may have important prognostic value as a biomarker of aGVHD after a prospective analysis of peripheral blood Tregs as determined by the frequency of CD4(+)CD25(hi)FOXP3(+) lymphocytes in 215 BMT patients.