T
Tania Azam
Researcher at University of Colorado Denver
Publications - 57
Citations - 5726
Tania Azam is an academic researcher from University of Colorado Denver. The author has contributed to research in topics: Cytokine & Proinflammatory cytokine. The author has an hindex of 32, co-authored 55 publications receiving 4908 citations. Previous affiliations of Tania Azam include Anschutz Medical Campus & University of Colorado Boulder.
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Journal ArticleDOI
Interleukin-32: A Cytokine and Inducer of TNFα
TL;DR: Induced in human peripheral lymphocyte cells after mitogen stimulation, in human epithelial cells by IFNgamma, and in NK cells after exposure to the combination of IL-12 plus IL-18, IL-32 may play a role in inflammatory/autoimmune diseases.
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The antitumor histone deacetylase inhibitor suberoylanilide hydroxamic acid exhibits antiinflammatory properties via suppression of cytokines
Flavio Leoni,Andrea Zaliani,Giorgio Bertolini,Giulia Porro,Paolo Pagani,Pietro Pozzi,Giancarlo Dona,Gianluca Fossati,Silvano Sozzani,Silvano Sozzani,Tania Azam,Philip Bufler,Giamila Fantuzzi,Igor Goncharov,Soo-Hyun Kim,Pomerantz Benjamin,Leonid L. Reznikov,Britta Siegmund,Charles A. Dinarello,Paolo Mascagni +19 more
TL;DR: It is found that SAHA reduces the production of proinflammatory cytokines in vivo and in vitro and may stimulate the expression of genes that control the synthesis of cytokines and nitric oxide or hyperacetylate other targets.
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IL-37 requires the receptors IL-18Rα and IL-1R8 (SIGIRR) to carry out its multifaceted anti-inflammatory program upon innate signal transduction
Claudia A. Nold-Petry,Camden Lo,Ina Rudloff,Kirstin Elgass,Suzhao Li,Michael P. Gantier,Amelie S. Lotz-Havla,Søren W. Gersting,Steven X. Cho,Jason C. Lao,Andrew M. Ellisdon,Björn Rotter,Tania Azam,Niamh E. Mangan,Fernando J. Rossello,James C. Whisstock,Philip Bufler,Cecilia Garlanda,Alberto Mantovani,Charles A. Dinarello,Marcel F. Nold +20 more
TL;DR: Nold et al. as mentioned in this paper identified the receptor for IL-37 and clarified the molecular nature of the anti-inflammatory pathway induced by this cytokine, which is a member of the IL-1 family.
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IL-38 binds to the IL-36 receptor and has biological effects on immune cells similar to IL-36 receptor antagonist
Frank L. van de Veerdonk,Angela K. Stoeckman,Gouping Wu,Aaron N. Boeckermann,Tania Azam,Mihai G. Netea,Leo A. B. Joosten,Jos W. M. van der Meer,Ruyi Hao,Vassili Kalabokis,Charles A. Dinarello +10 more
TL;DR: Evidence is provided that IL-38 binds to theIL-36R, as does IL-36Ra, and that IL -38 and IL- 36Ra have similar biological effects on immune cells by engaging the IL-37 receptor.
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OLT1177, a β-sulfonyl nitrile compound, safe in humans, inhibits the NLRP3 inflammasome and reverses the metabolic cost of inflammation.
Carlo Marchetti,Benjamin J Swartzwelter,Fabia Gamboni,Charles Preston Neff,Katrin Richter,Tania Azam,Sonia Carta,Isak W. Tengesdal,Travis Nemkov,Angelo D'Alessandro,Curtis J. Henry,Gerald S. Jones,Scott A. Goodrich,Joseph P. St. Laurent,Terry M. Jones,Curtis L. Scribner,Robert B. Barrow,Roy D. Altman,Damaris B. Skouras,Marco Gattorno,Veronika Grau,Sabina Janciauskiene,Anna Rubartelli,Leo A. B. Joosten,Charles A. Dinarello,Charles A. Dinarello +25 more
TL;DR: It is demonstrated that OLT1177, an orally active β-sulfonyl nitrile molecule, inhibits activation of the NLRP3 inflammasome, with unique properties to reverse the metabolic costs of inflammation and to treat IL-1β– and IL-18–mediated diseases.