P
Paolo Mignatti
Researcher at New York University
Publications - 94
Citations - 10159
Paolo Mignatti is an academic researcher from New York University. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 41, co-authored 93 publications receiving 9654 citations. Previous affiliations of Paolo Mignatti include University of Pavia & University of L'Aquila.
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Journal ArticleDOI
Biology and biochemistry of proteinases in tumor invasion
Paolo Mignatti,Daniel B. Rifkin +1 more
Journal ArticleDOI
Fibroblast Growth Factor-2 (FGF-2) Induces Vascular Endothelial Growth Factor (VEGF) Expression in the Endothelial Cells of Forming Capillaries: An Autocrine Mechanism Contributing to Angiogenesis
Graziano Seghezzi,Sundeep Patel,Christine J. Ren,Anna Gualandris,Giuseppe Pintucci,Edith S. Robbins,Richard L. Shapiro,Aubrey C. Galloway,Daniel B. Rifkin,Paolo Mignatti +9 more
TL;DR: Angiogenesis in vivo can be modulated by a novel mechanism that involves the autocrine action of vascular endothelial cell-derived FGF-2 and VEGF and is demonstrated to be an important autocrine mediator of F GF-2-induced angiogenesis.
Journal ArticleDOI
Tumor invasion through the human amniotic membrane: Requirement for a proteinase cascade
TL;DR: To understand the role of proteinases in tumor invasion, the effects of inhibitors of metallo-, serine-, and cysteine-proteinases on this process were studied using 125I-iododeoxyuridine-labeled B16/BL6 cells grown on human amnion basement membrane.
Journal ArticleDOI
Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum-Golgi complex.
TL;DR: BFGF can be released via a mechanism of exocytosis independent of the ER‐Golgi pathway, and the effects on cell motility of drugs or treatments known to affect various pathways of protein secretion were examined.
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In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.
TL;DR: Results obtained show that both the plasminogen activator-plasmin system and specific collagenases are involved in the invasive process occurring during angiogenesis.